Mending leaky blood vessels: The angiopoietin-Tie2 pathway in sepsis

Sascha David, Philipp Kümpers, Paul Van Slyke, Samir M. Parikh

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Sepsis is a systemic inflammatory response to infection. A common end-feature, these patients regularly suffer from is the so-called multiple organ dysfunction syndrome, an often fatal consequence of organ hypoperfusion, coagulopathy, immune dysregulation, and mitochondrial dysfunction. Microvascular dysfunction critically contributes to the morbidity and mortality of this disease. The angiopoietin (Angpt)/Tie2 system consists of the transmembrane endothelial tyrosine kinase Tie2 and its circulating ligands (Angpt-1, -2, and -3/4). The balance between the canonical agonist Angpt-1 and its competitive inhibitor, Angpt-2, regulates basal endothelial barrier function and the leakage and vascular inflammation that develop in response to pathogens and cytokines. Here we summarize recent work in mice and men to highlight the therapeutic potential in this pathway to prevent or even reverse microvascular dysfunction in this deadly disease.

Original languageEnglish (US)
Pages (from-to)2-6
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume345
Issue number1
DOIs
StatePublished - Apr 2013
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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