Mesenchymal stem cells and tissue engineering for orthopaedic surgery.

J. Gao, A. I. Caplan

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Bone marrow contains multipotent mesenchymal stem cells (MSCs) that can differentiate into different mesenchymal lineages whose end-stage cells fabricate bone, cartilage, tendon, fat, and other connective tissues. Our laboratory has been focusing on the purification, culture expansion, the in vivo and the in vitro characterization of MSCs and their descendants. Given the large number of MSCs that can be generated, we have explored their use in different pre-clinical models utilizing the therapeutic potentials of MSCs for musculoskeletal disorders. Using newly evolved tissue engineering principals, we have focus on the treatment of full thickness cartilage damage and, separately, bone non-union. The experimental results suggest the MSCs may provide a powerful therapeutic tool for the treatment of musculoskeletal disorders. Future efforts should be made to establish reliable and standardized full-scale clinical approaches using MSCs for orthopaedic surgery.

Original languageEnglish (US)
Pages (from-to)305-316
Number of pages12
JournalLa Chirurgia degli organi di movimento
Volume88
Issue number3
StatePublished - 2003

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Cell Engineering
Tissue Engineering
Mesenchymal Stromal Cells
Orthopedics
Cartilage
Multipotent Stem Cells
Bone and Bones
Tendons
Connective Tissue
Bone Marrow
Fats
Therapeutics

Cite this

Mesenchymal stem cells and tissue engineering for orthopaedic surgery. / Gao, J.; Caplan, A. I.

In: La Chirurgia degli organi di movimento, Vol. 88, No. 3, 2003, p. 305-316.

Research output: Contribution to journalArticle

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