Meta-analyses of gabapentinoids for pain management after knee arthroplasty: A caveat emptor? A narrative review

Girish P. Joshi; Henrik Kehlet

doi:10.1111/aas.13820

Meta-analyses of gabapentinoids for pain management after knee arthroplasty: A caveat emptor? A narrative review

Girish P. Joshi, Henrik Kehlet

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

The use of gabapentinoids for perioperative pain management after total knee arthroplasty has been the subject of nine systematic reviews and meta-analyses. A critical analysis of the clinical aspects of the methodology of these publications shows major flaws which limit the interpretation for the recommended use of perioperative gabapentinoids in pain management for unilateral primary total knee arthroplasty. Consequently, readers and authors of systematic reviews and meta-analyses should critically assess the clinical aspects of the included studies.

Original language	English (US)
Pages (from-to)	865-869
Number of pages	5
Journal	Acta Anaesthesiologica Scandinavica
Volume	65
Issue number	7
DOIs	https://doi.org/10.1111/aas.13820
State	Published - Aug 2021

Keywords

TKA
gabapentinoids
meta-analyses
pain management

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1111/aas.13820

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title = "Meta-analyses of gabapentinoids for pain management after knee arthroplasty: A caveat emptor? A narrative review",

abstract = "The use of gabapentinoids for perioperative pain management after total knee arthroplasty has been the subject of nine systematic reviews and meta-analyses. A critical analysis of the clinical aspects of the methodology of these publications shows major flaws which limit the interpretation for the recommended use of perioperative gabapentinoids in pain management for unilateral primary total knee arthroplasty. Consequently, readers and authors of systematic reviews and meta-analyses should critically assess the clinical aspects of the included studies.",

keywords = "TKA, gabapentinoids, meta-analyses, pain management",

author = "Joshi, {Girish P.} and Henrik Kehlet",

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AU - Joshi, Girish P.

AU - Kehlet, Henrik

PY - 2021/8

Y1 - 2021/8

N2 - The use of gabapentinoids for perioperative pain management after total knee arthroplasty has been the subject of nine systematic reviews and meta-analyses. A critical analysis of the clinical aspects of the methodology of these publications shows major flaws which limit the interpretation for the recommended use of perioperative gabapentinoids in pain management for unilateral primary total knee arthroplasty. Consequently, readers and authors of systematic reviews and meta-analyses should critically assess the clinical aspects of the included studies.

AB - The use of gabapentinoids for perioperative pain management after total knee arthroplasty has been the subject of nine systematic reviews and meta-analyses. A critical analysis of the clinical aspects of the methodology of these publications shows major flaws which limit the interpretation for the recommended use of perioperative gabapentinoids in pain management for unilateral primary total knee arthroplasty. Consequently, readers and authors of systematic reviews and meta-analyses should critically assess the clinical aspects of the included studies.

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Meta-analyses of gabapentinoids for pain management after knee arthroplasty: A caveat emptor? A narrative review

Abstract

Keywords

ASJC Scopus subject areas

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