Meta-analyses of gabapentinoids for pain management after knee arthroplasty: A caveat emptor? A narrative review

Girish P. Joshi, Henrik Kehlet

Research output: Contribution to journalReview articlepeer-review

Abstract

The use of gabapentinoids for perioperative pain management after total knee arthroplasty has been the subject of nine systematic reviews and meta-analyses. A critical analysis of the clinical aspects of the methodology of these publications shows major flaws which limit the interpretation for the recommended use of perioperative gabapentinoids in pain management for unilateral primary total knee arthroplasty. Consequently, readers and authors of systematic reviews and meta-analyses should critically assess the clinical aspects of the included studies.

Original languageEnglish (US)
Pages (from-to)865-869
Number of pages5
JournalActa Anaesthesiologica Scandinavica
Volume65
Issue number7
DOIs
StatePublished - Aug 2021

Keywords

  • TKA
  • gabapentinoids
  • meta-analyses
  • pain management

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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