TY - JOUR
T1 - Metabolic control of autophagy
AU - Galluzzi, Lorenzo
AU - Pietrocola, Federico
AU - Levine, Beth
AU - Kroemer, Guido
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/12/4
Y1 - 2014/12/4
N2 - Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation to adverse microenvironmental conditions, including limited nutrient supplies. Several sensors interacting with the autophagic machinery have evolved to detect fluctuations in key metabolic parameters. The signal transduction cascades operating downstream of these sensors are highly interconnected to control a spatially and chronologically coordinated autophagic response that maintains the health and function of individual cells while preserving organismal homeostasis. Here, we discuss the physiological regulation of autophagy by metabolic circuitries, as well as alterations of such control in disease.
AB - Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation to adverse microenvironmental conditions, including limited nutrient supplies. Several sensors interacting with the autophagic machinery have evolved to detect fluctuations in key metabolic parameters. The signal transduction cascades operating downstream of these sensors are highly interconnected to control a spatially and chronologically coordinated autophagic response that maintains the health and function of individual cells while preserving organismal homeostasis. Here, we discuss the physiological regulation of autophagy by metabolic circuitries, as well as alterations of such control in disease.
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U2 - 10.1016/j.cell.2014.11.006
DO - 10.1016/j.cell.2014.11.006
M3 - Review article
C2 - 25480292
AN - SCOPUS:84923562561
SN - 0092-8674
VL - 159
SP - 1263
EP - 1276
JO - Cell
JF - Cell
IS - 6
ER -