Metabolic control of autophagy

Lorenzo Galluzzi, Federico Pietrocola, Beth Levine, Guido Kroemer

Research output: Contribution to journalReview article

412 Scopus citations

Abstract

Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation to adverse microenvironmental conditions, including limited nutrient supplies. Several sensors interacting with the autophagic machinery have evolved to detect fluctuations in key metabolic parameters. The signal transduction cascades operating downstream of these sensors are highly interconnected to control a spatially and chronologically coordinated autophagic response that maintains the health and function of individual cells while preserving organismal homeostasis. Here, we discuss the physiological regulation of autophagy by metabolic circuitries, as well as alterations of such control in disease.

Original languageEnglish (US)
Pages (from-to)1263-1276
Number of pages14
JournalCell
Volume159
Issue number6
DOIs
StatePublished - Dec 4 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014). Metabolic control of autophagy. Cell, 159(6), 1263-1276. https://doi.org/10.1016/j.cell.2014.11.006