Metabolic regulation of mitochondrial dynamics

Prashant Mishra, David C. Chan

Research output: Contribution to journalArticle

344 Scopus citations

Abstract

Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the same time, these organelles are highly dynamic and undergo fusion, fission, transport, and degradation. Each of these dynamic processes is critical for maintaining a healthy mitochondrial population. Given the central metabolic function of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally influence each other. We review the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.

Original languageEnglish (US)
Pages (from-to)379-387
Number of pages9
JournalJournal of Cell Biology
Volume212
Issue number4
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Cell Biology

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