Metabolic reprogramming and cancer progression

Brandon Faubert, Ashley Solmonson, Ralph J. DeBerardinis

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

Metabolic reprogramming is a hallmark ofmalignancy. As our understanding of the complexity of tumor biology increases, so does our appreciation of the complexity of tumor metabolism. Metabolic heterogeneity among human tumors poses a challenge to developing therapies that exploit metabolic vulnerabilities. Recent work also demonstrates that the metabolic properties and preferences of a tumor change during cancer progression. This produces distinct sets of vulnerabilities between primary tumors and metastatic cancer, even in the same patient or experimental model. We review emerging concepts about metabolic reprogramming in cancer, with particular attention on why metabolic properties evolve during cancer progression and how this information might be used to develop better therapeutic strategies.

Original languageEnglish (US)
Article numbereaaw5473
JournalScience
Volume368
Issue number6487
DOIs
StatePublished - Apr 10 2020

ASJC Scopus subject areas

  • General

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