Abstract
The core apparatus that regulates circadian rhythm has been extensively studied over the past five years. A looming question remains, however, regarding how this apparatus is adjusted to maintain coordination between physiology and the changing environment. The diversity of stimuli and input pathways that gain access to the circadian clock are summarized. Cellular metabolic states could serve to link physiologic perception of the environment to the circadian oscillatory apparatus. A simple model, integrating biochemical, cellular, and physiologic data, is presented to account for the connection of cellular metabolism and circadian rhythm.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 307-331 |
| Number of pages | 25 |
| Journal | Annual Review of Biochemistry |
| Volume | 71 |
| DOIs | |
| State | Published - 2002 |
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Keywords
- Central circadian oscillator
- Circadian rhythm
- Entrainment
- Neural activity
- Restricted feeding
- Suprachiasmatic nucleus
ASJC Scopus subject areas
- Biochemistry
Cite this
Metabolism and the control of circadian rhythms. / Rutter, Jared; Reick, Martin; McKnight, Steven L.
In: Annual Review of Biochemistry, Vol. 71, 2002, p. 307-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolism and the control of circadian rhythms
AU - Rutter, Jared
AU - Reick, Martin
AU - McKnight, Steven L.
PY - 2002
Y1 - 2002
N2 - The core apparatus that regulates circadian rhythm has been extensively studied over the past five years. A looming question remains, however, regarding how this apparatus is adjusted to maintain coordination between physiology and the changing environment. The diversity of stimuli and input pathways that gain access to the circadian clock are summarized. Cellular metabolic states could serve to link physiologic perception of the environment to the circadian oscillatory apparatus. A simple model, integrating biochemical, cellular, and physiologic data, is presented to account for the connection of cellular metabolism and circadian rhythm.
AB - The core apparatus that regulates circadian rhythm has been extensively studied over the past five years. A looming question remains, however, regarding how this apparatus is adjusted to maintain coordination between physiology and the changing environment. The diversity of stimuli and input pathways that gain access to the circadian clock are summarized. Cellular metabolic states could serve to link physiologic perception of the environment to the circadian oscillatory apparatus. A simple model, integrating biochemical, cellular, and physiologic data, is presented to account for the connection of cellular metabolism and circadian rhythm.
KW - Central circadian oscillator
KW - Circadian rhythm
KW - Entrainment
KW - Neural activity
KW - Restricted feeding
KW - Suprachiasmatic nucleus
UR - http://www.scopus.com/inward/record.url?scp=0035997367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035997367&partnerID=8YFLogxK
U2 - 10.1146/annurev.biochem.71.090501.142857
DO - 10.1146/annurev.biochem.71.090501.142857
M3 - Article
C2 - 12045099
AN - SCOPUS:0035997367
VL - 71
SP - 307
EP - 331
JO - Annual Review of Biochemistry
JF - Annual Review of Biochemistry
SN - 0066-4154
ER -