Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus

J. J. Abrams, H. Ginsberg, Scott M Grundy

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

The metabolism of cholesterol and plasma triglycerides (TG) was studied in 14 diabetic men: these patients did not have marked obesity nor did they develop ketoacidosis without insulin. Before insulin therapy, measurements were made of (1) plasma lipoproteins, (2) postheparin lipolytic enzymes, (3) turnover of TG in very-low-density lipoproteins (VLDL) and chylomicrons, (4) cholesterol balance, and (5) biliary lipids. After baseline measurements, the patients were treated with enough long-acting insulin to maintain their fasting plasma glucose in the range of 100-125 mg/dl. When plasma glucose and lipid levels reached a new steady state, all of the above measurements were repeated. Before insulin, most patients had fasting hypertriglyceridemia. This was due mainly to overproduction of VLDL-TG. Insulin therapy lowered both synthesis and concentrations of VLDL-TG to near normal. Also, patients with normotriglyceridemia, both before and during insulin therapy, had essentially normal clearance of chylomicrons. Those with high fasting TG had delayed clearance of chylomicrons, but clearance returned to normal in most with insulin therapy. Postheparin lipolytic enzymes were not decreased. Before insulin, synthesis rates of cholesterol and bile acids usually were greater than normal, and bile commonly was supersaturated with cholesterol. During insulin therapy, synthesis of both cholesterol and bile acids remained elevated, possibly because of imperfect control of hyperglycemia. Furthermore, saturation of bile with cholesterol was accentuated by insulin therapy.

Original languageEnglish (US)
Pages (from-to)903-910
Number of pages8
JournalDiabetes
Volume31
Issue number10
StatePublished - 1982

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Diabetes Mellitus
Triglycerides
Cholesterol
Insulin
Chylomicrons
Fasting
Bile Acids and Salts
Bile
Therapeutics
Long-Acting Insulin
Lipids
Glucose
Ketosis
Hypertriglyceridemia
Enzymes
Hyperglycemia
Lipoproteins
Obesity
very low density lipoprotein triglyceride

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus. / Abrams, J. J.; Ginsberg, H.; Grundy, Scott M.

In: Diabetes, Vol. 31, No. 10, 1982, p. 903-910.

Research output: Contribution to journalArticle

Abrams, J. J. ; Ginsberg, H. ; Grundy, Scott M. / Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus. In: Diabetes. 1982 ; Vol. 31, No. 10. pp. 903-910.
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