Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study)

Darae Ko, Eric M. Riles, Ernaldo G. Marcos, Jared W. Magnani, Steven A. Lubitz, Honghuang Lin, Michelle T. Long, Renate B. Schnabel, David D. McManus, Patrick T. Ellinor, Vasan S. Ramachandran, Thomas J. Wang, Robert E. Gerszten, Emelia J. Benjamin, Xiaoyan Yin, Michiel Rienstra

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Previous studies have shown several metabolic biomarkers to be associated with prevalent and incident atrial fibrillation (AF), but the results have not been replicated. We investigated metabolite profiles of 2,458 European ancestry participants from the Framingham Heart Study without AF at the index examination and followed them for 10 years for new-onset AF. Amino acids, organic acids, lipids, and other plasma metabolites were profiled by liquid chromatography–tandem mass spectrometry using fasting plasma samples. We conducted Cox proportional hazard analyses for association between metabolites and new-onset AF. We performed hypothesis-generating analysis to identify novel metabolites and hypothesis-testing analysis to confirm the previously reported associations between metabolites and AF. Mean age was 55.1 ± 9.9 years, and 53% were women. Incident AF developed in 156 participants (6.3%) in 10 years of follow-up. A total of 217 metabolites were examined, consisting of 54 positively charged metabolites, 59 negatively charged metabolites, and 104 lipids. None of the 217 metabolites met our a priori specified Bonferroni corrected level of significance in the multivariate analyses. We were unable to replicate previous results demonstrating associations between metabolites that we had measured and AF. In conclusion, in our metabolomics approach, none of the metabolites we tested were significantly associated with the risk of future AF.

Original languageEnglish (US)
Pages (from-to)1493-1496
Number of pages4
JournalAmerican Journal of Cardiology
Volume118
Issue number10
DOIs
StatePublished - Nov 15 2016
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Ko, D., Riles, E. M., Marcos, E. G., Magnani, J. W., Lubitz, S. A., Lin, H., Long, M. T., Schnabel, R. B., McManus, D. D., Ellinor, P. T., Ramachandran, V. S., Wang, T. J., Gerszten, R. E., Benjamin, E. J., Yin, X., & Rienstra, M. (2016). Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study). American Journal of Cardiology, 118(10), 1493-1496. https://doi.org/10.1016/j.amjcard.2016.08.010