Metastatic melanoma is a rapidly progressive, incurable malignancy for which novel therapies are needed. Analysis of the biology of melanoma cells reveals a dependency upon several critical pathways, with matrix metalloproteinases (MMPs) essential for tumor spread and dissemination. We describe a growing number of protein therapeutics which target melanoma cells by requiring activation by MMPs. These agents should have distinct side effects and may be useful in combinations with standard-cytotoxic chemotherapy or immunotherapies.
ASJC Scopus subject areas
- Pharmacology (medical)