methotrexate-resistant Leishmania donovani genetically deficient in the folate-methotrexate transporter

Medicine & Life Sciences

• Folic Acid Transporters 100%
• Leishmania donovani 76%
• Folic Acid 55%
• Methotrexate 54%
• Leishmania 21%
• Pteridines 20%
• Aminopterin 20%
• Folic Acid Antagonists 17%
• Parasites 15%
• Biopterin 9%
• Growth 9%
• Pyrimethamine 8%
• Thymine 8%
• Antimetabolites 8%
• Tetrahydrofolate Dehydrogenase 8%
• Trimethoprim 8%
• Membrane Transport Proteins 7%
• pyrimidine 7%
• Gene Amplification 7%
• purine 7%
• Thymidine 6%
• Clone Cells 4%
• Cell Line 3%
• Population 2%

Chemical Compounds

• Folate 67%
• Methotrexate 56%
• Dihydrofolates 28%
• Biopterin 18%
• Pyrimethamine 17%
• Pteridines 16%
• Antimetabolite 16%
• Antifolate 16%
• Pteridine 15%
• Trimethoprim 15%
• Resistance 14%
• Growth Inhibition 13%
• Thymidine 12%
• Thymine 12%
• Purine 11%
• Pyrimidine 10%
• Strain 7%