Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The current results show that one can exploit the normal regulation of receptor synthesis to stimulate the single normal gene in FH heterozygotes to produce an increased number of LDL receptors. This stimulation can be achieved by drugs that inhibit HMG CoA reductase in the liver and by maneuvers that cause bile acid depletion. These two therapeutic approaches are most effective when they are combined. It seems reasonable to speculate that such a profound lowering of plasma cholesterol levels will minimize the development of atherosclerosis in FH heterozygotes. In a broader sense, the success of this regulatory manipulation raises the possibility that other genetic diseases may be treated through manipulation of regulatory signals that control the rates of synthesis of gene products.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalTransactions of the Association of American Physicians
Volume96
StatePublished - 1983

Fingerprint

Lovastatin
Hyperlipoproteinemia Type II
Heterozygote
LDL Lipoproteins
Hydroxymethylglutaryl CoA Reductases
Inborn Genetic Diseases
LDL Receptors
Bile Acids and Salts
Genes
Atherosclerosis
Cholesterol
Liver
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{11a8c3c4b1394ace8667ba11035167ad,
title = "Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.",
abstract = "The current results show that one can exploit the normal regulation of receptor synthesis to stimulate the single normal gene in FH heterozygotes to produce an increased number of LDL receptors. This stimulation can be achieved by drugs that inhibit HMG CoA reductase in the liver and by maneuvers that cause bile acid depletion. These two therapeutic approaches are most effective when they are combined. It seems reasonable to speculate that such a profound lowering of plasma cholesterol levels will minimize the development of atherosclerosis in FH heterozygotes. In a broader sense, the success of this regulatory manipulation raises the possibility that other genetic diseases may be treated through manipulation of regulatory signals that control the rates of synthesis of gene products.",
author = "Bilheimer, {D. W.} and Grundy, {Scott M} and Brown, {Michael S} and Goldstein, {Joseph L}",
year = "1983",
language = "English (US)",
volume = "96",
pages = "1--9",
journal = "Transactions of the Association of American Physicians",
issn = "0066-9458",

}

TY - JOUR

T1 - Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

AU - Bilheimer, D. W.

AU - Grundy, Scott M

AU - Brown, Michael S

AU - Goldstein, Joseph L

PY - 1983

Y1 - 1983

N2 - The current results show that one can exploit the normal regulation of receptor synthesis to stimulate the single normal gene in FH heterozygotes to produce an increased number of LDL receptors. This stimulation can be achieved by drugs that inhibit HMG CoA reductase in the liver and by maneuvers that cause bile acid depletion. These two therapeutic approaches are most effective when they are combined. It seems reasonable to speculate that such a profound lowering of plasma cholesterol levels will minimize the development of atherosclerosis in FH heterozygotes. In a broader sense, the success of this regulatory manipulation raises the possibility that other genetic diseases may be treated through manipulation of regulatory signals that control the rates of synthesis of gene products.

AB - The current results show that one can exploit the normal regulation of receptor synthesis to stimulate the single normal gene in FH heterozygotes to produce an increased number of LDL receptors. This stimulation can be achieved by drugs that inhibit HMG CoA reductase in the liver and by maneuvers that cause bile acid depletion. These two therapeutic approaches are most effective when they are combined. It seems reasonable to speculate that such a profound lowering of plasma cholesterol levels will minimize the development of atherosclerosis in FH heterozygotes. In a broader sense, the success of this regulatory manipulation raises the possibility that other genetic diseases may be treated through manipulation of regulatory signals that control the rates of synthesis of gene products.

UR - http://www.scopus.com/inward/record.url?scp=0020899787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020899787&partnerID=8YFLogxK

M3 - Article

C2 - 6388097

AN - SCOPUS:0020899787

VL - 96

SP - 1

EP - 9

JO - Transactions of the Association of American Physicians

JF - Transactions of the Association of American Physicians

SN - 0066-9458

ER -