Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System

Victoria A. Acosta-Rodríguez, Marleen H.M. de Groot, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.

Original languageEnglish (US)
Pages (from-to)267-277.e2
JournalCell Metabolism
Volume26
Issue number1
DOIs
StatePublished - Jul 5 2017

Fingerprint

Caloric Restriction
Eating
Running
Meals
Automation
Feeding Behavior
Mammals
Rodentia
Fasting
Appointments and Schedules
Food

Keywords

  • alternate day feeding
  • automated feeder system
  • body weight
  • caloric restriction
  • circadian rhythm
  • feeding pattern
  • intermittent fasting
  • mouse
  • temporal restriction
  • wheel-running activity

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. / Acosta-Rodríguez, Victoria A.; de Groot, Marleen H.M.; Rijo-Ferreira, Filipa; Green, Carla B.; Takahashi, Joseph S.

In: Cell Metabolism, Vol. 26, No. 1, 05.07.2017, p. 267-277.e2.

Research output: Contribution to journalArticle

Acosta-Rodríguez, Victoria A. ; de Groot, Marleen H.M. ; Rijo-Ferreira, Filipa ; Green, Carla B. ; Takahashi, Joseph S. / Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. In: Cell Metabolism. 2017 ; Vol. 26, No. 1. pp. 267-277.e2.
@article{4d235420ddd947c0bd1ec67f37759f7f,
title = "Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System",
abstract = "Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.",
keywords = "alternate day feeding, automated feeder system, body weight, caloric restriction, circadian rhythm, feeding pattern, intermittent fasting, mouse, temporal restriction, wheel-running activity",
author = "Acosta-Rodr{\'i}guez, {Victoria A.} and {de Groot}, {Marleen H.M.} and Filipa Rijo-Ferreira and Green, {Carla B.} and Takahashi, {Joseph S.}",
year = "2017",
month = "7",
day = "5",
doi = "10.1016/j.cmet.2017.06.007",
language = "English (US)",
volume = "26",
pages = "267--277.e2",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System

AU - Acosta-Rodríguez, Victoria A.

AU - de Groot, Marleen H.M.

AU - Rijo-Ferreira, Filipa

AU - Green, Carla B.

AU - Takahashi, Joseph S.

PY - 2017/7/5

Y1 - 2017/7/5

N2 - Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.

AB - Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.

KW - alternate day feeding

KW - automated feeder system

KW - body weight

KW - caloric restriction

KW - circadian rhythm

KW - feeding pattern

KW - intermittent fasting

KW - mouse

KW - temporal restriction

KW - wheel-running activity

UR - http://www.scopus.com/inward/record.url?scp=85021370753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021370753&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2017.06.007

DO - 10.1016/j.cmet.2017.06.007

M3 - Article

C2 - 28683292

AN - SCOPUS:85021370753

VL - 26

SP - 267-277.e2

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -