TY - JOUR
T1 - Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System
AU - Acosta-Rodríguez, Victoria A.
AU - de Groot, Marleen H.M.
AU - Rijo-Ferreira, Filipa
AU - Green, Carla B.
AU - Takahashi, Joseph S.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/7/5
Y1 - 2017/7/5
N2 - Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.
AB - Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.
KW - alternate day feeding
KW - automated feeder system
KW - body weight
KW - caloric restriction
KW - circadian rhythm
KW - feeding pattern
KW - intermittent fasting
KW - mouse
KW - temporal restriction
KW - wheel-running activity
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U2 - 10.1016/j.cmet.2017.06.007
DO - 10.1016/j.cmet.2017.06.007
M3 - Article
C2 - 28683292
AN - SCOPUS:85021370753
SN - 1550-4131
VL - 26
SP - 267-277.e2
JO - Cell Metabolism
JF - Cell Metabolism
IS - 1
ER -