Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System

Victoria A. Acosta-Rodríguez, Marleen H.M. de Groot, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.

Original languageEnglish (US)
Pages (from-to)267-277.e2
JournalCell Metabolism
Volume26
Issue number1
DOIs
StatePublished - Jul 5 2017

Keywords

  • alternate day feeding
  • automated feeder system
  • body weight
  • caloric restriction
  • circadian rhythm
  • feeding pattern
  • intermittent fasting
  • mouse
  • temporal restriction
  • wheel-running activity

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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