TY - GEN
T1 - Micromachined nanoporous membranes for blood oxygenation systems
AU - Ambravaneswaran, Vijayakrishnan
AU - Uttamaraj, Susheil
AU - Çelik-Butler, Zeynep
AU - Eberhart, Robert C.
AU - Chuong, Charles J.
AU - Billo, Richard E.
AU - Savitt, Michael A.
PY - 2008
Y1 - 2008
N2 - Nanostructured membranes with precisely engineered nanopores were fabricated on a thin silicon nitride membrane, using a combination of bulk micromachining and focused-ion-beam drilling. These membranes are designed to preserve microscale blood channel dimensions, thereby permitting the red cell shape change that enhances gas exchange in the pulmonary capillary. The membranes were tested for their mechanical stability and the results were verified with finite element analysis. Initial studies have proven the membranes to be robust, and capable of withstanding pressures typically experienced in blood oxygenator channels. A novel MEMS-based blood oxygenation system employing the nanoporous membranes is also presented. The oxygenation system is designed to have controlled blood and gas volumes for efficient blood oxygenation.
AB - Nanostructured membranes with precisely engineered nanopores were fabricated on a thin silicon nitride membrane, using a combination of bulk micromachining and focused-ion-beam drilling. These membranes are designed to preserve microscale blood channel dimensions, thereby permitting the red cell shape change that enhances gas exchange in the pulmonary capillary. The membranes were tested for their mechanical stability and the results were verified with finite element analysis. Initial studies have proven the membranes to be robust, and capable of withstanding pressures typically experienced in blood oxygenator channels. A novel MEMS-based blood oxygenation system employing the nanoporous membranes is also presented. The oxygenation system is designed to have controlled blood and gas volumes for efficient blood oxygenation.
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U2 - 10.1109/NANO.2008.66
DO - 10.1109/NANO.2008.66
M3 - Conference contribution
AN - SCOPUS:55349109294
SN - 9781424421046
T3 - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
SP - 201
EP - 204
BT - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
PB - IEEE Computer Society
T2 - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
Y2 - 18 August 2008 through 21 August 2008
ER -