MicroPET: A high resolution PET scanner for imaging small animals

S. R. Cherry, Y. Shao, R. W. Silverman, K. Meadors, S. Siegel, A. Chatziioannou, J. W. Young, W. F. Jones, J. C. Moyers, D. Newport, A. Boutefnouchet, T. H. Farquhar, M. Andreaco, M. J. Paulus, D. M. Binkley, R. Nutt, M. E. Phelps

Research output: Contribution to journalArticle

472 Citations (Scopus)

Abstract

MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 positionsensitive scintillation detectors, each with an 8 x 8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm3. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50 - 75 mnA Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.

Original languageEnglish (US)
Pages (from-to)1161-1166
Number of pages6
JournalIEEE Transactions on Nuclear Science
Volume44
Issue number3 PART 2
DOIs
StatePublished - Dec 1 1997

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Positron emission tomography
scanners
animals
positrons
Animals
tomography
Imaging techniques
high resolution
Lutetium
rings
Detectors
detectors
Scintillation counters
Photomultipliers
Image resolution
septum
lutetium
Phosphors
image resolution
Optical fibers

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering

Cite this

Cherry, S. R., Shao, Y., Silverman, R. W., Meadors, K., Siegel, S., Chatziioannou, A., ... Phelps, M. E. (1997). MicroPET: A high resolution PET scanner for imaging small animals. IEEE Transactions on Nuclear Science, 44(3 PART 2), 1161-1166. https://doi.org/10.1109/23.596981

MicroPET : A high resolution PET scanner for imaging small animals. / Cherry, S. R.; Shao, Y.; Silverman, R. W.; Meadors, K.; Siegel, S.; Chatziioannou, A.; Young, J. W.; Jones, W. F.; Moyers, J. C.; Newport, D.; Boutefnouchet, A.; Farquhar, T. H.; Andreaco, M.; Paulus, M. J.; Binkley, D. M.; Nutt, R.; Phelps, M. E.

In: IEEE Transactions on Nuclear Science, Vol. 44, No. 3 PART 2, 01.12.1997, p. 1161-1166.

Research output: Contribution to journalArticle

Cherry, SR, Shao, Y, Silverman, RW, Meadors, K, Siegel, S, Chatziioannou, A, Young, JW, Jones, WF, Moyers, JC, Newport, D, Boutefnouchet, A, Farquhar, TH, Andreaco, M, Paulus, MJ, Binkley, DM, Nutt, R & Phelps, ME 1997, 'MicroPET: A high resolution PET scanner for imaging small animals', IEEE Transactions on Nuclear Science, vol. 44, no. 3 PART 2, pp. 1161-1166. https://doi.org/10.1109/23.596981
Cherry SR, Shao Y, Silverman RW, Meadors K, Siegel S, Chatziioannou A et al. MicroPET: A high resolution PET scanner for imaging small animals. IEEE Transactions on Nuclear Science. 1997 Dec 1;44(3 PART 2):1161-1166. https://doi.org/10.1109/23.596981
Cherry, S. R. ; Shao, Y. ; Silverman, R. W. ; Meadors, K. ; Siegel, S. ; Chatziioannou, A. ; Young, J. W. ; Jones, W. F. ; Moyers, J. C. ; Newport, D. ; Boutefnouchet, A. ; Farquhar, T. H. ; Andreaco, M. ; Paulus, M. J. ; Binkley, D. M. ; Nutt, R. ; Phelps, M. E. / MicroPET : A high resolution PET scanner for imaging small animals. In: IEEE Transactions on Nuclear Science. 1997 ; Vol. 44, No. 3 PART 2. pp. 1161-1166.
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