MicroRNA regulation of neural stem cells and neurogenesis

Yanhong Shi, Xinyu Zhao, Jenny Hsieh, Hynek Wichterle, Soren Impey, Sourav Banerjee, Pierre Neveu, Kenneth S. Kosik

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

MicroRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, and plasticity. The emerging concept is that microRNAs play a central role in controlling the balance between stem cell self-renewal and fate determination by regulating the expression of stem cell regulators. This review will highlight recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs. It will cover microRNA functions during the entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal maturation, synaptic formation, and plasticity. The interplay between microRNAs and both cell-intrinsic and -extrinsic stem cell players, including transcription factors, epigenetic regulators, and extrinsic signaling molecules will be discussed. This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject.

Original languageEnglish (US)
Pages (from-to)14931-14936
Number of pages6
JournalJournal of Neuroscience
Volume30
Issue number45
DOIs
StatePublished - Nov 10 2010

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Neural Stem Cells
Neurogenesis
MicroRNAs
Stem Cells
Neuronal Plasticity
Epigenomics
Transcription Factors
RNA
Cell Self Renewal

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Shi, Y., Zhao, X., Hsieh, J., Wichterle, H., Impey, S., Banerjee, S., ... Kosik, K. S. (2010). MicroRNA regulation of neural stem cells and neurogenesis. Journal of Neuroscience, 30(45), 14931-14936. https://doi.org/10.1523/JNEUROSCI.4280-10.2010

MicroRNA regulation of neural stem cells and neurogenesis. / Shi, Yanhong; Zhao, Xinyu; Hsieh, Jenny; Wichterle, Hynek; Impey, Soren; Banerjee, Sourav; Neveu, Pierre; Kosik, Kenneth S.

In: Journal of Neuroscience, Vol. 30, No. 45, 10.11.2010, p. 14931-14936.

Research output: Contribution to journalArticle

Shi, Y, Zhao, X, Hsieh, J, Wichterle, H, Impey, S, Banerjee, S, Neveu, P & Kosik, KS 2010, 'MicroRNA regulation of neural stem cells and neurogenesis', Journal of Neuroscience, vol. 30, no. 45, pp. 14931-14936. https://doi.org/10.1523/JNEUROSCI.4280-10.2010
Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S et al. MicroRNA regulation of neural stem cells and neurogenesis. Journal of Neuroscience. 2010 Nov 10;30(45):14931-14936. https://doi.org/10.1523/JNEUROSCI.4280-10.2010
Shi, Yanhong ; Zhao, Xinyu ; Hsieh, Jenny ; Wichterle, Hynek ; Impey, Soren ; Banerjee, Sourav ; Neveu, Pierre ; Kosik, Kenneth S. / MicroRNA regulation of neural stem cells and neurogenesis. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 45. pp. 14931-14936.
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