MicroRNA regulation of neural stem cells and neurogenesis

Yanhong Shi, Xinyu Zhao, Jenny Hsieh, Hynek Wichterle, Soren Impey, Sourav Banerjee, Pierre Neveu, Kenneth S. Kosik

Research output: Contribution to journalArticle

152 Scopus citations

Abstract

MicroRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, and plasticity. The emerging concept is that microRNAs play a central role in controlling the balance between stem cell self-renewal and fate determination by regulating the expression of stem cell regulators. This review will highlight recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs. It will cover microRNA functions during the entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal maturation, synaptic formation, and plasticity. The interplay between microRNAs and both cell-intrinsic and -extrinsic stem cell players, including transcription factors, epigenetic regulators, and extrinsic signaling molecules will be discussed. This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject.

Original languageEnglish (US)
Pages (from-to)14931-14936
Number of pages6
JournalJournal of Neuroscience
Volume30
Issue number45
DOIs
StatePublished - Nov 10 2010

ASJC Scopus subject areas

  • Neuroscience(all)

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    Shi, Y., Zhao, X., Hsieh, J., Wichterle, H., Impey, S., Banerjee, S., Neveu, P., & Kosik, K. S. (2010). MicroRNA regulation of neural stem cells and neurogenesis. Journal of Neuroscience, 30(45), 14931-14936. https://doi.org/10.1523/JNEUROSCI.4280-10.2010