MicroRNAs as potential drug targets for therapeutic intervention in colorectal cancer

Mohammad Alam Jafri, Syed Kashif Zaidi, Shakeel Ahmed Ansari, Mohammed Hussein Al-Qahtani, Jerry W. Shay

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Introduction: MicroRNAs (miRNAs) are small (19 - 22 nucleotide), non-protein-coding RNA segments that function as master regulators of hundreds of genes simultaneously in both normal and malignant cells. In colorectal cancer (CRC) miRNAs are deregulated and have critical roles in initiation and progression of CRC by interacting with various oncogenes and tumor suppressor genes including APC, KRAS and p53, or by modulating downstream signal transduction pathways. Numerous promising miRNAs have emerged as potential drug targets for therapeutic intervention and possible candidates for replacement therapy in CRC. Areas covered: In this review the authors summarize the available information on miRNAs and their role in CRC. The authors point out specific miRNAs as potential drug targets and those having a significant role in gene activation and gene silencing during the process of CRC development, to highlight their importance as possible therapeutic candidates for the treatment of CRC. Expert opinion: Targeting miRNAs provides an emerging opportunity to develop effective miRNA-based replacement therapy or antagonists to alter expression in colon cancer patient tumors. However, the biggest challenge is to overcome obstacles associated with pharmacokinetics, delivery and toxicity in order to translate the potential of miRNAs into efficacious anticancer drugs.

Original languageEnglish (US)
Pages (from-to)1705-1723
Number of pages19
JournalExpert Opinion on Therapeutic Targets
Volume19
Issue number12
DOIs
StatePublished - Dec 2 2015

Keywords

  • antagomirs
  • anti-microRNA oligonucleotides
  • colon cancer
  • genomic instability
  • microRNA dysregulation
  • microRNA mimics
  • microRNA silencing
  • replacement therapy

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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