MicroRNAs in inflammatory bowel disease

Joel R. Pekow, John H. Kwon

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene and protein expression. miRNAs are critical to a normal immune response and have altered expression in multiple immune-mediated disorders. This emerging role of miRNAs in the pathogenesis of multiple disease states has led to investigations into miRNA expression profiles in inflammatory bowel disease (IBD). The discovery of miRNAs in IBD is likely to contribute to our understanding of IBD pathogenesis and lead to clinical advances in IBD. This review focuses on miRNA expression in inflammation, autoimmune disorders, and inflammation-associated cancer, as well as their function in the biology and management of IBD.

Original languageEnglish (US)
Pages (from-to)187-193
Number of pages7
JournalInflammatory bowel diseases
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2012

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Keywords

  • IBD
  • inflammatory bowel disease
  • microRNAs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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