Microsomal cytochrome P450 and eicosanoid metabolism

J. H. Capdevila, R. C. Harris, J R Falck

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

The demonstration of a role for microsomal P450 in the metabolism of endogenous pools of arachidonic acid established this enzyme system as a member of the arachidonic acid cascade and characterized a new an important metabolic function for this enzyme system. Studies from several laboratories documenting the powerful biological activities of the P450-derived eicosanoids have suggested important roles for the P450 arachidonic acid monooxygenase in renal and vascular physiology, and in the pathophysiology of experimental hypertension. These studies provide significant evidence to indicate that in addition to its recognized traditional toxicological and pharmacological roles, microsomal P450s also play important physiological roles in the control of tissue and body homeostasis.

Original languageEnglish (US)
Pages (from-to)780-789
Number of pages10
JournalCellular and Molecular Life Sciences
Volume59
Issue number5
DOIs
StatePublished - Jun 24 2002

Keywords

  • Arachidonic acid monooxygenase
  • Fatty acid hydroxylases
  • P450 eicosanoids
  • P450 epoxygenases
  • P450 ω-hydroxylases, EETs
  • ω-alcohols

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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