Abstract
The demonstration of a role for microsomal P450 in the metabolism of endogenous pools of arachidonic acid established this enzyme system as a member of the arachidonic acid cascade and characterized a new an important metabolic function for this enzyme system. Studies from several laboratories documenting the powerful biological activities of the P450-derived eicosanoids have suggested important roles for the P450 arachidonic acid monooxygenase in renal and vascular physiology, and in the pathophysiology of experimental hypertension. These studies provide significant evidence to indicate that in addition to its recognized traditional toxicological and pharmacological roles, microsomal P450s also play important physiological roles in the control of tissue and body homeostasis.
Original language | English (US) |
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Pages (from-to) | 780-789 |
Number of pages | 10 |
Journal | Cellular and Molecular Life Sciences |
Volume | 59 |
Issue number | 5 |
DOIs | |
State | Published - 2002 |
Keywords
- Arachidonic acid monooxygenase
- Fatty acid hydroxylases
- P450 eicosanoids
- P450 epoxygenases
- P450 ω-hydroxylases, EETs
- ω-alcohols
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Cellular and Molecular Neuroscience
- Cell Biology