Microwave ablation in a hepatic porcine model

Correlation of CT and histopathologic findings

Michael M. Awad, Lara Devgan, Ihab R. Kamel, Michael Torbensen, Michael A. Choti

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background. Thermal ablative techniques have gained increasing popularity in recent years as safe and effective options for patients with unresectable solid malignancies. Microwave ablation has emerged as a relatively new technique with the promise of larger and faster burns without some of the limitations of radiofrequency ablation (RFA). Here we study a new microwave ablation device in a living porcine model using gross, histologic, and radiographic analysis. Materials and methods. The size and shape of ablated lesions were assessed using six pigs in a non-survival study. Liver tissue was ablated using 2, 4, and 8 min burns, in both peripheral and central locations, with and without vascular inflow occlusion. To characterize the post-ablation appearance, three additional pigs underwent several 4 min ablations each followed by serial computed tomography (CT) imaging at 7, 14, and 28 days postoperatively. Results. The 2 and 4 min ablations resulted in lesions that were similar in size, 33.5 cm3 and 37.5 cm3, respectively. Ablations lasting 8 min produced lesions that were significantly larger, 92.0 cm3 on average. Proximity to hepatic vasculature and inflow occlusion did not significantly change lesion size or shape. In follow-up studies, CT imaging showed a gradual reduction in lesion volume over 28 days to 25-50% of the original volume. Discussion. Microwave ablation with a novel device results in consistently sized and shaped lesions. Importantly, we did not observe any significant heat-sink effect using this device, a major difference from RFA techniques. This system offers a viable alternative for creating fast, large ablation volumes for treatment in liver cancer.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalHPB
Volume9
Issue number5
DOIs
StatePublished - 2007

Fingerprint

Microwaves
Swine
Tomography
Burns
Equipment and Supplies
Liver
Hot Temperature
Ablation Techniques
Liver Neoplasms
Blood Vessels
Neoplasms

Keywords

  • Ablation
  • Cancer
  • Hepatocellular
  • Liver
  • Metastatic
  • Microwave
  • Porcine
  • Thermal

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Microwave ablation in a hepatic porcine model : Correlation of CT and histopathologic findings. / Awad, Michael M.; Devgan, Lara; Kamel, Ihab R.; Torbensen, Michael; Choti, Michael A.

In: HPB, Vol. 9, No. 5, 2007, p. 357-362.

Research output: Contribution to journalArticle

Awad, Michael M. ; Devgan, Lara ; Kamel, Ihab R. ; Torbensen, Michael ; Choti, Michael A. / Microwave ablation in a hepatic porcine model : Correlation of CT and histopathologic findings. In: HPB. 2007 ; Vol. 9, No. 5. pp. 357-362.
@article{a98bd81c61784a26b3812c93202293d9,
title = "Microwave ablation in a hepatic porcine model: Correlation of CT and histopathologic findings",
abstract = "Background. Thermal ablative techniques have gained increasing popularity in recent years as safe and effective options for patients with unresectable solid malignancies. Microwave ablation has emerged as a relatively new technique with the promise of larger and faster burns without some of the limitations of radiofrequency ablation (RFA). Here we study a new microwave ablation device in a living porcine model using gross, histologic, and radiographic analysis. Materials and methods. The size and shape of ablated lesions were assessed using six pigs in a non-survival study. Liver tissue was ablated using 2, 4, and 8 min burns, in both peripheral and central locations, with and without vascular inflow occlusion. To characterize the post-ablation appearance, three additional pigs underwent several 4 min ablations each followed by serial computed tomography (CT) imaging at 7, 14, and 28 days postoperatively. Results. The 2 and 4 min ablations resulted in lesions that were similar in size, 33.5 cm3 and 37.5 cm3, respectively. Ablations lasting 8 min produced lesions that were significantly larger, 92.0 cm3 on average. Proximity to hepatic vasculature and inflow occlusion did not significantly change lesion size or shape. In follow-up studies, CT imaging showed a gradual reduction in lesion volume over 28 days to 25-50{\%} of the original volume. Discussion. Microwave ablation with a novel device results in consistently sized and shaped lesions. Importantly, we did not observe any significant heat-sink effect using this device, a major difference from RFA techniques. This system offers a viable alternative for creating fast, large ablation volumes for treatment in liver cancer.",
keywords = "Ablation, Cancer, Hepatocellular, Liver, Metastatic, Microwave, Porcine, Thermal",
author = "Awad, {Michael M.} and Lara Devgan and Kamel, {Ihab R.} and Michael Torbensen and Choti, {Michael A.}",
year = "2007",
doi = "10.1080/13651820701646222",
language = "English (US)",
volume = "9",
pages = "357--362",
journal = "HPB",
issn = "1365-182X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Microwave ablation in a hepatic porcine model

T2 - Correlation of CT and histopathologic findings

AU - Awad, Michael M.

AU - Devgan, Lara

AU - Kamel, Ihab R.

AU - Torbensen, Michael

AU - Choti, Michael A.

PY - 2007

Y1 - 2007

N2 - Background. Thermal ablative techniques have gained increasing popularity in recent years as safe and effective options for patients with unresectable solid malignancies. Microwave ablation has emerged as a relatively new technique with the promise of larger and faster burns without some of the limitations of radiofrequency ablation (RFA). Here we study a new microwave ablation device in a living porcine model using gross, histologic, and radiographic analysis. Materials and methods. The size and shape of ablated lesions were assessed using six pigs in a non-survival study. Liver tissue was ablated using 2, 4, and 8 min burns, in both peripheral and central locations, with and without vascular inflow occlusion. To characterize the post-ablation appearance, three additional pigs underwent several 4 min ablations each followed by serial computed tomography (CT) imaging at 7, 14, and 28 days postoperatively. Results. The 2 and 4 min ablations resulted in lesions that were similar in size, 33.5 cm3 and 37.5 cm3, respectively. Ablations lasting 8 min produced lesions that were significantly larger, 92.0 cm3 on average. Proximity to hepatic vasculature and inflow occlusion did not significantly change lesion size or shape. In follow-up studies, CT imaging showed a gradual reduction in lesion volume over 28 days to 25-50% of the original volume. Discussion. Microwave ablation with a novel device results in consistently sized and shaped lesions. Importantly, we did not observe any significant heat-sink effect using this device, a major difference from RFA techniques. This system offers a viable alternative for creating fast, large ablation volumes for treatment in liver cancer.

AB - Background. Thermal ablative techniques have gained increasing popularity in recent years as safe and effective options for patients with unresectable solid malignancies. Microwave ablation has emerged as a relatively new technique with the promise of larger and faster burns without some of the limitations of radiofrequency ablation (RFA). Here we study a new microwave ablation device in a living porcine model using gross, histologic, and radiographic analysis. Materials and methods. The size and shape of ablated lesions were assessed using six pigs in a non-survival study. Liver tissue was ablated using 2, 4, and 8 min burns, in both peripheral and central locations, with and without vascular inflow occlusion. To characterize the post-ablation appearance, three additional pigs underwent several 4 min ablations each followed by serial computed tomography (CT) imaging at 7, 14, and 28 days postoperatively. Results. The 2 and 4 min ablations resulted in lesions that were similar in size, 33.5 cm3 and 37.5 cm3, respectively. Ablations lasting 8 min produced lesions that were significantly larger, 92.0 cm3 on average. Proximity to hepatic vasculature and inflow occlusion did not significantly change lesion size or shape. In follow-up studies, CT imaging showed a gradual reduction in lesion volume over 28 days to 25-50% of the original volume. Discussion. Microwave ablation with a novel device results in consistently sized and shaped lesions. Importantly, we did not observe any significant heat-sink effect using this device, a major difference from RFA techniques. This system offers a viable alternative for creating fast, large ablation volumes for treatment in liver cancer.

KW - Ablation

KW - Cancer

KW - Hepatocellular

KW - Liver

KW - Metastatic

KW - Microwave

KW - Porcine

KW - Thermal

UR - http://www.scopus.com/inward/record.url?scp=35348976135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35348976135&partnerID=8YFLogxK

U2 - 10.1080/13651820701646222

DO - 10.1080/13651820701646222

M3 - Article

VL - 9

SP - 357

EP - 362

JO - HPB

JF - HPB

SN - 1365-182X

IS - 5

ER -