Miniaturized detection technology in molecular diagnostics

Larry J. Kricka, Jason Y. Park, Sam F Y Li, Paolo Fortina

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Miniaturization of genetic tests represents the convergence of molecular biology and engineering and is leading to a new class of small analyzers and test systems for genetic testing with improved analytical characteristics. Miniaturization initially focused on devices that contained micrometer-sized features designed for a particular analytical purpose (e.g., filters for cell isolation and chips for capillary electrophoresis). Now, the focus is shifting to analytical applications based on nano-sized objects such as nanotubes, nanochannels, nanoparticles, nanopores and nanocapacitors. These nanofabricated objects provide new tools for sequencing of nucleic acids and rapid, multiplexed, nucleic acid detection.

Original languageEnglish (US)
Pages (from-to)549-559
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume5
Issue number4
DOIs
StatePublished - Jul 1 2005

Keywords

  • Carbon nanotube
  • Electrochemical detection
  • Microchip CE
  • Multiplexing
  • Nanoparticles
  • Nanopore
  • Nanotechnology
  • Non-PCR testing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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