Minimal stimulation protocol for assisted reproductive technologies in women with diminished ovarian reserve and/or advanced reproductive age

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We present the minimal stimulation protocol for assisted reproductive technologies (ART) that we recommend for women with diminished ovarian reserve and/or advanced reproductive age. The protocol is individualized for each patient reflecting the heterogeneity of this patient population. The minimal stimulation requires assuring the follicle synchronization while keeping LH unsuppressed. Daily clomiphene citrate and, in some cases, daily letrozole are used throughout the entirety of the stimulation. Highly purified human menopausal gonadotropin is added on day 5 of stimulation to be used at 150 IU every other day. Close monitoring allows individualization of half-dose gonadotropin antagonist administration to prevent premature luteinizing hormone surge. This protocol is aimed at accumulating frozen embryos for elective frozen-thawed embryo transfer. Minimal stimulation for ART requires specific conditions and many allocated resources.

Original languageEnglish (US)
Title of host publicationDiminished Ovarian Reserve and Assisted Reproductive Technologies
Subtitle of host publicationCurrent Research and Clinical Management
PublisherSpringer International Publishing
Pages157-174
Number of pages18
ISBN (Electronic)9783030232351
ISBN (Print)9783030232344
DOIs
StatePublished - Jan 1 2019

Keywords

  • Advanced reproductive age
  • ART
  • Assisted reproductive technology
  • Diminished ovarian reserve
  • IVF
  • Minimal stimulation

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

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