TY - JOUR
T1 - Minimized tolerance to the suppressive effects of CCK8 on operant responding
AU - Cohen, Steven L.
AU - Knight, Martha
AU - Tamminga, Carol A.
AU - Chase, Thomas N.
N1 - Funding Information:
This research was supported in part by Grant IR03 MH37423-01 from the National Institute of Mental Health. 2 To whom reprint requests should be addressed: Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, Pa. 17815.
PY - 1983/9
Y1 - 1983/9
N2 - This study was designed to determine if tolerance to cholecystokinin octapeptide (CCK8) could be prevented or minimized by spacing injections, and if an appetitive operant conditioning paradigm provides a sensitive baseline to test the effects of CCK8. Male Sprague-Dawley rats were trained to press a lever for water according to a fixed-interval 60-sec schedule of reinforcement. After response rate stabilized, rats were given a series of CCK8 (0.04 mg/kg, ip) injections spaced several days apart. The first injection of CCK8 produced complete response suppression during the 30-min test session, while later injections produced partial or complete suppression. Thus, tolerance to CCK8, as measured by operant response rate, may be minimized if injections are appropriately spaced.
AB - This study was designed to determine if tolerance to cholecystokinin octapeptide (CCK8) could be prevented or minimized by spacing injections, and if an appetitive operant conditioning paradigm provides a sensitive baseline to test the effects of CCK8. Male Sprague-Dawley rats were trained to press a lever for water according to a fixed-interval 60-sec schedule of reinforcement. After response rate stabilized, rats were given a series of CCK8 (0.04 mg/kg, ip) injections spaced several days apart. The first injection of CCK8 produced complete response suppression during the 30-min test session, while later injections produced partial or complete suppression. Thus, tolerance to CCK8, as measured by operant response rate, may be minimized if injections are appropriately spaced.
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U2 - 10.1016/S0163-1047(83)90705-7
DO - 10.1016/S0163-1047(83)90705-7
M3 - Article
C2 - 6318716
AN - SCOPUS:0021062058
SN - 0163-1047
VL - 39
SP - 123
EP - 127
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 1
ER -