Minireview

Evolution of NURSA, the Nuclear Receptor Signaling Atlas

Neil J. McKenna, Austin J. Cooney, Francesco J. Demayo, Michael Downes, Christopher K. Glass, Rainer B. Lanz, Mitchell A. Lazar, David J. Mangelsdorf, David D. Moore, Jun Qin, David L. Steffen, Ming Jer Tsai, Sophia Y. Tsai, Ruth Yu, Ronald N. Margolis, Ronald M. Evans, Bert W. O'Malley

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Nuclear receptors and coregulators are multifaceted players in normal metabolic and homeostatic processes in addition to a variety of disease states including cancer, inflammation, diabetes, obesity, and atherosclerosis. Over the past 7 yr, the Nuclear Receptor Signaling Atlas (NURSA) research consortium has worked toward establishing a discovery-driven platform designed to address key questions concerning the expression, organization, and function of these molecules in a variety of experimental model systems. By applying powerful technologies such as quantitative PCR, high-throughput mass spectrometry, and embryonic stem cell manipulation, we are pursuing these questions in a series of transcriptomics-, proteomics-, and metabolomics-based research projects and resources. The consortium's web site (www.nursa.org) integrates NURSA datasets and existing public datasets with the ultimate goal of furnishing the bench scientist with a comprehensive framework for hypothesis generation, modeling, and testing. We place a strong emphasis on community input into the development of this resource and to this end have published datasets from academic and industrial laboratories, established strategic alliances with Endocrine Society journals, and are developing tools to allow web site users to act as data curators. With the ongoing support of the nuclear receptor and coregulator signaling communities, we believe that NURSA can make a lasting contribution to research in this dynamic field.

Original languageEnglish (US)
Pages (from-to)740-746
Number of pages7
JournalMolecular Endocrinology
Volume23
Issue number6
DOIs
StatePublished - Jun 2009

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Atlases
Cytoplasmic and Nuclear Receptors
Research
Metabolomics
Embryonic Stem Cells
Proteomics
Mass Spectrometry
Atherosclerosis
Theoretical Models
Obesity
Organizations
Inflammation
Technology
Polymerase Chain Reaction
Datasets
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

McKenna, N. J., Cooney, A. J., Demayo, F. J., Downes, M., Glass, C. K., Lanz, R. B., ... O'Malley, B. W. (2009). Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Molecular Endocrinology, 23(6), 740-746. https://doi.org/10.1210/me.2009-0135

Minireview : Evolution of NURSA, the Nuclear Receptor Signaling Atlas. / McKenna, Neil J.; Cooney, Austin J.; Demayo, Francesco J.; Downes, Michael; Glass, Christopher K.; Lanz, Rainer B.; Lazar, Mitchell A.; Mangelsdorf, David J.; Moore, David D.; Qin, Jun; Steffen, David L.; Tsai, Ming Jer; Tsai, Sophia Y.; Yu, Ruth; Margolis, Ronald N.; Evans, Ronald M.; O'Malley, Bert W.

In: Molecular Endocrinology, Vol. 23, No. 6, 06.2009, p. 740-746.

Research output: Contribution to journalArticle

McKenna, NJ, Cooney, AJ, Demayo, FJ, Downes, M, Glass, CK, Lanz, RB, Lazar, MA, Mangelsdorf, DJ, Moore, DD, Qin, J, Steffen, DL, Tsai, MJ, Tsai, SY, Yu, R, Margolis, RN, Evans, RM & O'Malley, BW 2009, 'Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas', Molecular Endocrinology, vol. 23, no. 6, pp. 740-746. https://doi.org/10.1210/me.2009-0135
McKenna NJ, Cooney AJ, Demayo FJ, Downes M, Glass CK, Lanz RB et al. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Molecular Endocrinology. 2009 Jun;23(6):740-746. https://doi.org/10.1210/me.2009-0135
McKenna, Neil J. ; Cooney, Austin J. ; Demayo, Francesco J. ; Downes, Michael ; Glass, Christopher K. ; Lanz, Rainer B. ; Lazar, Mitchell A. ; Mangelsdorf, David J. ; Moore, David D. ; Qin, Jun ; Steffen, David L. ; Tsai, Ming Jer ; Tsai, Sophia Y. ; Yu, Ruth ; Margolis, Ronald N. ; Evans, Ronald M. ; O'Malley, Bert W. / Minireview : Evolution of NURSA, the Nuclear Receptor Signaling Atlas. In: Molecular Endocrinology. 2009 ; Vol. 23, No. 6. pp. 740-746.
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