Minor elective surgical procedures using general anesthesia in children with sickle cell anemia without pre-operative blood transfusion

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24 Citations (Scopus)

Abstract

Background. Pre-operative red blood cell (RBC) transfusions are often recommended for patients with sickle cell disease (SCD) who require elective surgery under general anesthesia. However, definitive randomized studies demonstrating the benefit of transfusions in this setting have not been conducted. In particular, the merits of transfusion prior to minor or low-risk surgical procedures in children with SCD have not been demonstrated. Procedure. We hypothesized that children with sickle cell anemia (Hb SS) who have minor elective surgical procedures develop few complications even without pre-operative transfusion. We accessed our Comprehensive Sickle Cell Program's Database to identify all such procedures performed during a 13-year period. Medical records were reviewed to characterize the surgical procedure, the use of transfusions, and perioperative complications. Results. Twenty-eight children with Hb SS had a total of 38 minor surgical procedures. No perioperative transfusions were given in 34 of the cases (85%). Five of these 34 surgeries (15%) were associated with minor post-operative complications (fever or transient pain). No post-operative acute chest syndrome was encountered. Conclusions. Minor or low-risk elective surgical procedures in children with Hb SS may not routinely require pre-operative transfusion. A randomized clinical trial to compare transfusion with no transfusion for minor surgical procedures is needed.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalPediatric Blood and Cancer
Volume45
Issue number1
DOIs
StatePublished - Jul 2005

Fingerprint

Elective Surgical Procedures
Minor Surgical Procedures
Sickle Cell Anemia
Blood Transfusion
General Anesthesia
Acute Chest Syndrome
Erythrocyte Transfusion
Medical Records
Fever
Randomized Controlled Trials
Databases
Pain

Keywords

  • General anesthesia
  • Operation
  • Sickle cell
  • Surgery
  • Transfusion

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

@article{085bf85acc5d45a6b8c2e70dede43bf8,
title = "Minor elective surgical procedures using general anesthesia in children with sickle cell anemia without pre-operative blood transfusion",
abstract = "Background. Pre-operative red blood cell (RBC) transfusions are often recommended for patients with sickle cell disease (SCD) who require elective surgery under general anesthesia. However, definitive randomized studies demonstrating the benefit of transfusions in this setting have not been conducted. In particular, the merits of transfusion prior to minor or low-risk surgical procedures in children with SCD have not been demonstrated. Procedure. We hypothesized that children with sickle cell anemia (Hb SS) who have minor elective surgical procedures develop few complications even without pre-operative transfusion. We accessed our Comprehensive Sickle Cell Program's Database to identify all such procedures performed during a 13-year period. Medical records were reviewed to characterize the surgical procedure, the use of transfusions, and perioperative complications. Results. Twenty-eight children with Hb SS had a total of 38 minor surgical procedures. No perioperative transfusions were given in 34 of the cases (85{\%}). Five of these 34 surgeries (15{\%}) were associated with minor post-operative complications (fever or transient pain). No post-operative acute chest syndrome was encountered. Conclusions. Minor or low-risk elective surgical procedures in children with Hb SS may not routinely require pre-operative transfusion. A randomized clinical trial to compare transfusion with no transfusion for minor surgical procedures is needed.",
keywords = "General anesthesia, Operation, Sickle cell, Surgery, Transfusion",
author = "Teresa Fu and Corrigan, {Nicole J.} and Quinn, {Charles T.} and Rogers, {Zora R.} and Buchanan, {George R.}",
year = "2005",
month = "7",
doi = "10.1002/pbc.20283",
language = "English (US)",
volume = "45",
pages = "43--47",
journal = "Pediatric Blood and Cancer",
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T1 - Minor elective surgical procedures using general anesthesia in children with sickle cell anemia without pre-operative blood transfusion

AU - Fu, Teresa

AU - Corrigan, Nicole J.

AU - Quinn, Charles T.

AU - Rogers, Zora R.

AU - Buchanan, George R.

PY - 2005/7

Y1 - 2005/7

N2 - Background. Pre-operative red blood cell (RBC) transfusions are often recommended for patients with sickle cell disease (SCD) who require elective surgery under general anesthesia. However, definitive randomized studies demonstrating the benefit of transfusions in this setting have not been conducted. In particular, the merits of transfusion prior to minor or low-risk surgical procedures in children with SCD have not been demonstrated. Procedure. We hypothesized that children with sickle cell anemia (Hb SS) who have minor elective surgical procedures develop few complications even without pre-operative transfusion. We accessed our Comprehensive Sickle Cell Program's Database to identify all such procedures performed during a 13-year period. Medical records were reviewed to characterize the surgical procedure, the use of transfusions, and perioperative complications. Results. Twenty-eight children with Hb SS had a total of 38 minor surgical procedures. No perioperative transfusions were given in 34 of the cases (85%). Five of these 34 surgeries (15%) were associated with minor post-operative complications (fever or transient pain). No post-operative acute chest syndrome was encountered. Conclusions. Minor or low-risk elective surgical procedures in children with Hb SS may not routinely require pre-operative transfusion. A randomized clinical trial to compare transfusion with no transfusion for minor surgical procedures is needed.

AB - Background. Pre-operative red blood cell (RBC) transfusions are often recommended for patients with sickle cell disease (SCD) who require elective surgery under general anesthesia. However, definitive randomized studies demonstrating the benefit of transfusions in this setting have not been conducted. In particular, the merits of transfusion prior to minor or low-risk surgical procedures in children with SCD have not been demonstrated. Procedure. We hypothesized that children with sickle cell anemia (Hb SS) who have minor elective surgical procedures develop few complications even without pre-operative transfusion. We accessed our Comprehensive Sickle Cell Program's Database to identify all such procedures performed during a 13-year period. Medical records were reviewed to characterize the surgical procedure, the use of transfusions, and perioperative complications. Results. Twenty-eight children with Hb SS had a total of 38 minor surgical procedures. No perioperative transfusions were given in 34 of the cases (85%). Five of these 34 surgeries (15%) were associated with minor post-operative complications (fever or transient pain). No post-operative acute chest syndrome was encountered. Conclusions. Minor or low-risk elective surgical procedures in children with Hb SS may not routinely require pre-operative transfusion. A randomized clinical trial to compare transfusion with no transfusion for minor surgical procedures is needed.

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KW - Operation

KW - Sickle cell

KW - Surgery

KW - Transfusion

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