Abstract
Histocompatibility antigens have been studied for over 50 years because they form a major obstacle to clinical transplantation. Human minor histocompatibility antigens remain ill-defined, but minor histocompatibility loci have been mapped on nearly every mouse chromosome. Recent molecular definition of several transplantation antigens suggests that they are by-products of an immune system poised to present viral antigens, and a mutation in any gene may give rise to a new minor histocompatibility antigen.
Original language | English (US) |
---|---|
Pages (from-to) | 219-224 |
Number of pages | 6 |
Journal | Trends in Genetics |
Volume | 7 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1991 |
ASJC Scopus subject areas
- Genetics