Minor histocompatibility antigens

Kirsten Fischer Lindahl

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Histocompatibility antigens have been studied for over 50 years because they form a major obstacle to clinical transplantation. Human minor histocompatibility antigens remain ill-defined, but minor histocompatibility loci have been mapped on nearly every mouse chromosome. Recent molecular definition of several transplantation antigens suggests that they are by-products of an immune system poised to present viral antigens, and a mutation in any gene may give rise to a new minor histocompatibility antigen.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalTrends in Genetics
Volume7
Issue number7
DOIs
StatePublished - Jul 1991

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ASJC Scopus subject areas

  • Genetics

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