Mixed phenotype acute leukemia (MPAL)

Olga Weinberg

doi:10.4267/2042/68920

Mixed phenotype acute leukemia (MPAL)

Olga Weinberg

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Mixed phenotype acute leukemia (MPAL) accounts for 2-5% of all acute leukemias (Weinberg OK et al., 2010). The World Health Organization (WHO) classification of hematopoietic and lymphoid tumors proposed a simpler diagnostic algorithm, which relies on fewer and more lineage-specific markers to define MPAL. MPAL with t(9;22) and MLL rearrangement are now separate subtypes of MPAL and considered as distinct entities (Weir EG et al., 2010). Recent molecular studies demonstrates frequent epigenetic regulatory genes and tumor suppressor genes frequently present in MPAL.

Original language	English (US)
Pages (from-to)	292-294
Number of pages	3
Journal	Atlas of Genetics and Cytogenetics in Oncology and Haematology
Volume	22
Issue number	7
DOIs	https://doi.org/10.4267/2042/68920
State	Published - 2018
Externally published	Yes

Keywords

Mixed phenotype acute leukemia
World Health Organization

ASJC Scopus subject areas

Hematology
Oncology
Genetics
Cancer Research

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10.4267/2042/68920

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abstract = "Mixed phenotype acute leukemia (MPAL) accounts for 2-5% of all acute leukemias (Weinberg OK et al., 2010). The World Health Organization (WHO) classification of hematopoietic and lymphoid tumors proposed a simpler diagnostic algorithm, which relies on fewer and more lineage-specific markers to define MPAL. MPAL with t(9;22) and MLL rearrangement are now separate subtypes of MPAL and considered as distinct entities (Weir EG et al., 2010). Recent molecular studies demonstrates frequent epigenetic regulatory genes and tumor suppressor genes frequently present in MPAL.",

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AB - Mixed phenotype acute leukemia (MPAL) accounts for 2-5% of all acute leukemias (Weinberg OK et al., 2010). The World Health Organization (WHO) classification of hematopoietic and lymphoid tumors proposed a simpler diagnostic algorithm, which relies on fewer and more lineage-specific markers to define MPAL. MPAL with t(9;22) and MLL rearrangement are now separate subtypes of MPAL and considered as distinct entities (Weir EG et al., 2010). Recent molecular studies demonstrates frequent epigenetic regulatory genes and tumor suppressor genes frequently present in MPAL.

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KW - World Health Organization

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Mixed phenotype acute leukemia (MPAL)

Abstract

Keywords

ASJC Scopus subject areas

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