MKlf7, a potential transcriptional regulator of TrkA nerve growth factor receptor expression in sensory and sympathetic neurons

L. Lei, L. Ma, S. Nef, T. Thai, L. F. Parada

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Development of the nervous system relies on stringent regulation of genes that are crucial to this process. TrkA, the receptor for nerve growth factor (NGF), is tightly regulated during embryonic development and is essential for the survival and differentiation of neural crest-derived sensory and sympathetic neurons. We have previously identified a mouse TrkA enhancer and have characterized several cis regulatory elements that are important for appropriate TrkA expression in vivo. We now report the cloning of a novel gene encoding a Kruppel-like factor from a mouse dorsal root ganglion expression library. This Kruppel-like factor, named mKlf7, binds specifically to an Ikaros core binding element that is crucial for in vivo TrkA enhancer function. Using in situ hybridization, we demonstrate that mKlf7 is coexpressed with TrkA in sensory and sympathetic neurons during embryogenesis and in adulthood. These data are consistent with the idea that mKlf7 may directly regulate TrkA gene expression in the peripheral nervous system.

Original languageEnglish (US)
Pages (from-to)1147-1158
Number of pages12
JournalDevelopment
Volume128
Issue number7
StatePublished - May 15 2001

Keywords

  • Enhancer
  • Gene regulation
  • Kruppel-like factor
  • Mouse
  • Neural crest
  • Neurotrophin
  • TrkA

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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