Mobilization of glucoregulatory hormones and glucose by hypothalamic locomotor centers

J. Vissing, G. A. Iwamoto, K. J. Rybicki, H. Galbo, J. H. Mitchell

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Recent studies suggest that, in addition to classical humoral metabolic feedback mechanisms, the mobilization of glucoregulatory hormones and glucose in exercise may be regulated by motor centers in the brain. We, therefore, studied the effect of electrically stimulating the posterior hypothalamic locomotor region (PHLR) for 10 min in decorticated (n = 6) and α-chloralose-anesthetized (n = 8) cats. Blood pressure and heart rate were measured, and blood samples were drawn for analysis of hormones and metabolites before, during, and after 10 min of PHLR stimulation. Feedback from contracting muscles were prevented by neuromuscular blockade in decorticated cats and by the anesthesia in anesthetized cats. In decorticated cats, PHLR stimulation elicited increases (2 P < 0.05) in glucose production (Δ54 ± 16 μmol·min-1·kg-1), plasma glucose (Δ2.2 ± 0.7 mmol/l), epinephrine (Δ4.9 ± 1.8 pmol/l), norepinephrine (Δ2.2 ± 0.9 pmol/l), glucagon (Δ16 ± 5 pmol/l), decreased (2 P < 0.05) in plasma insulin (Δ27 ± 7 pmol/l), and increases (2 P < 0.05) in blood pressure (Δ48 ± 9 mmHg) and heart rate (Δ26 ± 7 beats/min). In anesthetized cats, PHLR stimulation elicited increases (2 P < 0.05) in glucose production (Δ12 ± 4 μmol·min-1·kg-1), plasma glucose (Δ0.4 ± 0.1 mmol/l), blood pressure (Δ39 ± 7 mmHg), and heart rate (Δ28 ± 7 beats/min), whereas changes in catecholamine and insulin concentrations did not reach statistical significance. These results provide the first direct evidence for the view that hormonal and metabolic, as well as cardiovascular, exercise responses may be evoked in parallel with locomotion by activation of motor centers in the brain.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume257
Issue number5
StatePublished - 1989

Fingerprint

Hypothalamic Hormones
Posterior Hypothalamus
Cats
Hormones
Blood pressure
Glucose
Heart Rate
Blood Pressure
Plasmas
Brain
Insulin
Feedback
Chloralose
Neuromuscular Blockade
Locomotion
Metabolites
Glucagon
Epinephrine
Catecholamines
Muscle

Keywords

  • α-Chloralose
  • Cat
  • Central command
  • Decortication
  • Epinephrine
  • Exercise
  • Glucagon
  • Glucose turnover
  • Insulin
  • Norepinephrine
  • Posterior hypothalamic locomotor region

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

Cite this

Mobilization of glucoregulatory hormones and glucose by hypothalamic locomotor centers. / Vissing, J.; Iwamoto, G. A.; Rybicki, K. J.; Galbo, H.; Mitchell, J. H.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 257, No. 5, 1989.

Research output: Contribution to journalArticle

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