Model for a recognition of 3-methyladenine by 3-methyladenine dna glycosylase: The stacking interaction between 3-methyladenine and indole rings

Y. Yamagata, M. Kato, S. Fujii

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

X-Ray crystallographic study shows that 3-methyladenine, the product of methylation of DNA by carcinogenic and/or mutagenic methylating agents, stacks strongly with the indole ring, the aromatic side group of tryptophan.

Original languageEnglish (US)
Pages (from-to)2385-2387
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume42
Issue number11
StatePublished - 1994

Fingerprint

Methylation
DNA Methylation
Tryptophan
X-Rays
X rays
DNA
indole
3-methyladenine

Keywords

  • 3-Methyladenine-indole-3-acetic acid complex
  • Enzyme recognition model
  • Stacking interaction
  • X-ray analysis

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

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title = "Model for a recognition of 3-methyladenine by 3-methyladenine dna glycosylase: The stacking interaction between 3-methyladenine and indole rings",
abstract = "X-Ray crystallographic study shows that 3-methyladenine, the product of methylation of DNA by carcinogenic and/or mutagenic methylating agents, stacks strongly with the indole ring, the aromatic side group of tryptophan.",
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T2 - The stacking interaction between 3-methyladenine and indole rings

AU - Yamagata, Y.

AU - Kato, M.

AU - Fujii, S.

PY - 1994

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KW - Enzyme recognition model

KW - Stacking interaction

KW - X-ray analysis

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