Model for a recognition of 3-methyladenine by 3-methyladenine dna glycosylase: The stacking interaction between 3-methyladenine and indole rings

Y. Yamagata; M. Kato; S. Fujii

doi:10.1248/cpb.42.2385

Model for a recognition of 3-methyladenine by 3-methyladenine dna glycosylase: The stacking interaction between 3-methyladenine and indole rings

Y. Yamagata, M. Kato, S. Fujii

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

X-Ray crystallographic study shows that 3-methyladenine, the product of methylation of DNA by carcinogenic and/or mutagenic methylating agents, stacks strongly with the indole ring, the aromatic side group of tryntophan.

Original language	English (US)
Pages (from-to)	2385-2387
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	42
Issue number	11
DOIs	https://doi.org/10.1248/cpb.42.2385
State	Published - 1994

Keywords

3-methyladenine-indole-3-acetic acid complex
X-ray analysis
enzyme recognition model
stacking interaction

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.42.2385

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title = "Model for a recognition of 3-methyladenine by 3-methyladenine dna glycosylase: The stacking interaction between 3-methyladenine and indole rings",

abstract = "X-Ray crystallographic study shows that 3-methyladenine, the product of methylation of DNA by carcinogenic and/or mutagenic methylating agents, stacks strongly with the indole ring, the aromatic side group of tryntophan.",

keywords = "3-methyladenine-indole-3-acetic acid complex, X-ray analysis, enzyme recognition model, stacking interaction",

author = "Y. Yamagata and M. Kato and S. Fujii",

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AU - Kato, M.

AU - Fujii, S.

PY - 1994

Y1 - 1994

N2 - X-Ray crystallographic study shows that 3-methyladenine, the product of methylation of DNA by carcinogenic and/or mutagenic methylating agents, stacks strongly with the indole ring, the aromatic side group of tryntophan.

AB - X-Ray crystallographic study shows that 3-methyladenine, the product of methylation of DNA by carcinogenic and/or mutagenic methylating agents, stacks strongly with the indole ring, the aromatic side group of tryntophan.

KW - 3-methyladenine-indole-3-acetic acid complex

KW - X-ray analysis

KW - enzyme recognition model

KW - stacking interaction

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Model for a recognition of 3-methyladenine by 3-methyladenine dna glycosylase: The stacking interaction between 3-methyladenine and indole rings

Abstract

Keywords

ASJC Scopus subject areas

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