Model for a recognition of 3-methyladenine by 3-methyladenine dna glycosylase: The stacking interaction between 3-methyladenine and indole rings

Y. Yamagata, M. Kato, S. Fujii

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

X-Ray crystallographic study shows that 3-methyladenine, the product of methylation of DNA by carcinogenic and/or mutagenic methylating agents, stacks strongly with the indole ring, the aromatic side group of tryntophan.

Original languageEnglish (US)
Pages (from-to)2385-2387
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume42
Issue number11
DOIs
StatePublished - Jan 1 1994

Keywords

  • 3-methyladenine-indole-3-acetic acid complex
  • X-ray analysis
  • enzyme recognition model
  • stacking interaction

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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