Modular organization of the mammalian Golgi apparatus

Nobuhiro Nakamura, Jen Hsuan Wei, Joachim Seemann

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume24
Issue number4
DOIs
StatePublished - Aug 2012

ASJC Scopus subject areas

  • Cell Biology

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