Modular organization of the mammalian Golgi apparatus

Nobuhiro Nakamura; Jen Hsuan Wei; Joachim Seemann

doi:10.1016/j.ceb.2012.05.009

Modular organization of the mammalian Golgi apparatus

Nobuhiro Nakamura, Jen Hsuan Wei, Joachim Seemann

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.

Original language	English (US)
Pages (from-to)	467-474
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.ceb.2012.05.009
State	Published - Aug 2012

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2012.05.009

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title = "Modular organization of the mammalian Golgi apparatus",

abstract = "The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.",

author = "Nobuhiro Nakamura and Wei, {Jen Hsuan} and Joachim Seemann",

note = "Funding Information: The work in the laboratory of J.S. is supported by a grant from the National Institute of Health ( GM096070 ). N.N. is supported by a grant form Kyoto Sangyo University and the MEXT, Japan ( 24112525 ). ",

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AU - Wei, Jen Hsuan

AU - Seemann, Joachim

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N2 - The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.

AB - The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.

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Modular organization of the mammalian Golgi apparatus

Abstract

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