Molecular biology and biochemistry of the endothelins

Yanagisawa Masashi, Masaki Tomoh

Research output: Contribution to journalArticle

583 Citations (Scopus)

Abstract

Endothelin-1 (ET-1), the first member of the newly discovered mammalian endothelin family of biologically active peptides, was originally identified as a 21 residue potent vasoconstrictor peptide in vascular endothelial cells. However, it has since been demonstrated to possess a wide variety of pharmacological activities in tissues both within and outside the cardiovascular system, and peptides with a striking similarity to ET-1 have been found to be the major toxic component of a snake venom. Moreover, recent studies have suggested that mammals including humans produce three distinct members of this peptide family, ET-1, ET-2 and ET-J, which may have different profiles of biological activity, and may act on distinct subtypes of endothelin receptor. Masashi Yanagisawa and Tomoh Masaki review the current status of the biochemistry and molecular biology of endothelin.

Original languageEnglish (US)
Pages (from-to)374-378
Number of pages5
JournalTrends in Pharmacological Sciences
Volume10
Issue number9
DOIs
StatePublished - 1989

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Biochemistry
Molecular biology
Endothelins
Molecular Biology
Endothelin-1
Peptides
Cardiovascular system
Endothelin Receptors
Snake Venoms
Mammals
Poisons
Endothelial cells
Vasoconstrictor Agents
Cardiovascular System
Bioactivity
Endothelial Cells
Pharmacology
Tissue

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Molecular biology and biochemistry of the endothelins. / Masashi, Yanagisawa; Tomoh, Masaki.

In: Trends in Pharmacological Sciences, Vol. 10, No. 9, 1989, p. 374-378.

Research output: Contribution to journalArticle

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