Molecular mechanisms of the membrane sculpting ESCRT pathway

William Mike Henne, Harald Stenmark, Scott D. Emr

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The endosomal sorting complexes required for transport (ESCRT) drive multivesicular body (MVB) biogenesis and cytokinetic abscission. Originally identified through genetics and cell biology, more recent work has begun to elucidate the molecular mechanisms of ESCRT-mediated membrane remodeling, with special focus on the ESCRT-III complex. In particular, several light and electron microscopic studies provide high-resolution imaging of ESCRT-III rings and spirals that purportedly drive MVB morphogenesis and abscission. These studies highlight unifying principles to ESCRT-III function, in particular: (1) the ordered assembly of the ESCRT-III monomers into a heteropolymer, (2) ESCRT-III as a dynamic complex, and (3) the role of the AAA ATP asVps4 as a contributing factor in membrane scission. Mechanistic comparisons of ESCRT-III function in MVB morphogenesis and cytokinesis suggest common mechanisms in membrane remodeling.

Original languageEnglish (US)
Article numbera016766
JournalCold Spring Harbor perspectives in medicine
Volume3
Issue number10
StatePublished - 2013

Fingerprint

Endosomal Sorting Complexes Required for Transport
Membranes
Multivesicular Bodies
Morphogenesis
Cytology
Cytokinesis
Cell Biology
Adenosine Triphosphate
Monomers
Electrons
Imaging techniques
Light

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Molecular mechanisms of the membrane sculpting ESCRT pathway. / Henne, William Mike; Stenmark, Harald; Emr, Scott D.

In: Cold Spring Harbor perspectives in medicine, Vol. 3, No. 10, a016766, 2013.

Research output: Contribution to journalArticle

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