Molecular pathways and potential therapeutic targets in glioblastoma multiforme

Zabi Wardak, Kevin S. Choe

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Glioblastoma multiforme (GBM) is the most common primary brain malignancy. The current standard of therapy consists of surgical resection followed by concurrent chemoradiotherapy with temozolomide. Despite steady advances in all therapeutic modalities, clinical improvements have been slow and the prognosis remains poor. Utilizing powerful large-scale molecular techniques, several key pathways implicated in gliomagenesis have recently been identified and confirmed. These represent potential therapeutic targets, and by developing novel methods to specifically manipulate these pathways, we may achieve a meaningful and substantial improvement in the way we treat GBM. Here, we present and discuss the current status of research into the molecular pathways and potential therapeutic targets in GBM.

Original languageEnglish (US)
Pages (from-to)1307-1318
Number of pages12
JournalExpert Review of Anticancer Therapy
Volume13
Issue number11
DOIs
StatePublished - Nov 14 2013

Keywords

  • GBM
  • glioblastoma
  • glioma
  • glioma stem cells
  • molecular target
  • radiation
  • targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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