Molecular regulation of visual system development: More than meets the eye

Takayuki Harada, Chikako Harada, Luis F. Parada

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations

Abstract

Vertebrate eye development has been an excellent model system to investigate basic concepts of developmental biology ranging from mechanisms of tissue induction to the complex patterning and bidimensional orientation of the highly specialized retina. Recent advances have shed light on the interplay between numerous transcriptional networks and growth factors that are involved in the specific stages of retinogenesis, optic nerve formation, and topographic mapping. In this review, we summarize this recent progress on the molecular mechanisms underlying the development of the eye, visual system, and embryonic tumors that arise in the optic system.

Original languageEnglish (US)
Pages (from-to)367-378
Number of pages12
JournalGenes and Development
Volume21
Issue number4
DOIs
StatePublished - Feb 15 2007

Keywords

  • Axon guidance
  • Cancer
  • Degeneration and regeneration
  • Neurotrophins
  • Retinal development
  • Retinal ganglion cells
  • Topographic mapping

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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