Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging

J. Masciotti, F. Provenzano, J. Papa, A. Klose, J. Hur, X. Gu, D. Yamashiro, J. Kandel, A. H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Small animal models are employed to simulate disease in humans and to study its progression, what factors are important to the disease process, and to study the disease treatment. Biomedical imaging modalities such as magnetic resonance imaging (MRI) and Optical Tomography make it possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. MRI is an established imaging modality capable of obtaining high resolution anatomical images and along with contrast agents allow the studying of blood volume. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal resolution. In this study we apply these modalities to imaging the growth of kidney tumors and then there treatment by an anti-VEGF agent. We illustrate how these imaging modalities have their individual uses, but can still supplement each other and cross validation can be performed.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
DOIs
StatePublished - May 11 2006
EventMultimodal Biomedical Imaging - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6081
ISSN (Print)0277-786X

Other

OtherMultimodal Biomedical Imaging
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

Keywords

  • MRI
  • Multimodality Imaging
  • Optical Tomography
  • Small animal imaging
  • VEGF

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Masciotti, J., Provenzano, F., Papa, J., Klose, A., Hur, J., Gu, X., Yamashiro, D., Kandel, J., & Hielscher, A. H. (2006). Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging. In Proceedings of SPIE - The International Society for Optical Engineering [608105] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6081). https://doi.org/10.1117/12.647138