Monoclonal Antibodies against Human Monocytes: II. Recognition of Two Distinct Cell Surface Molecules

G. Nunez, V. Ugolini, J. D. Capra, P. Stastny

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Three monoclonal antibodies (63D3, 63D2, and 61D3) with reactivity against human monocytes have been studied. They reacted with most adherent mononuclear cells but not with pure populations of peripheral blood B and T lymphocytes. Two of these antibodies, 63D3 and 63D2, competed in fluorescence inhibition experiments, recognized a monocyte surface antigem of about 200,000 daltons, and werre idiotypically related. The third antibody, 61D3, did not compete with the others in fluorescence inhibition experiments, recognized a different surface molecule, and was idiotypically distinct from 63D3 and 63D2. Whereas 63D3 and 63D2 reacted very weakly with some granulucytes, 61D3 did not, suggesting that it is specific for monocytes alone.

Original languageEnglish (US)
Pages (from-to)515-523
Number of pages9
JournalScandinavian Journal of Immunology
Volume16
Issue number6
DOIs
StatePublished - Dec 1982

ASJC Scopus subject areas

  • Immunology

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