Morphologic Blooming in Breast MRI as a Characterization of Margin for Discriminating Benign from Malignant Lesions

Alan Penn, Scott Thompson, Rachel Brem, Constance Lehman, Paul Weatherall, Mitchell Schnall, Gillian Newstead, Emily Conant, Susan Ascher, Elizabeth Morris, Etta Pisano

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Rationale and Objectives: Develop a fully automated, objective method for evaluating morphology on breast magnetic resonance (MR) images and evaluate effectiveness of the new morphologic method for detecting breast cancers. Materials and Methods: We present a new automated method (morphologic blooming) for identifying and classifying breast lesions on MR that measures margin sharpness, a characteristic related to blooming, defined as rapid enhancement, with a border that is initially sharp but becomes unsharp after 7 minutes. Independent training sets (98 biopsy-proven lesions) and testing sets (179 breasts, 127 patients, acquired at five institutions) were used. Morphologic blooming was evaluated as a stand-alone feature and as an adjunct to kinetics using free-response receiver operating characteristic and sensitivity analysis. Dependence of false-positive (FP) rates on acquisition times and pathologies of contralateral breasts were evaluated. Results: Sensitivity of morphologic blooming was 80% with 2.46 FP per noncancerous breast: FPs did not vary significantly by acquisition times. FPs varied significantly by pathologies of contralateral breasts (cancerous contralateral: 4.29 FP/breast; noncancerous contralateral: 0.48 FP/breast; P < .0001). Evaluation of 45 cancers showed suspicious morphologies on 10/15 (67%) cancers with benign-like kinetics and suspicious kinetics on 5/10 (50%) cancers with benign-like morphologies. Conclusion: We present a new, fully automated method of identifying and classifying margin sharpness of breast lesions on MR that can be used to direct radiologists' attention to lesions with suspicious morphologies. Morphologic blooming may have important utility for assisting radiologists in identifying cancers with benign-like kinetics and discriminating normal tissues that exhibit cancer-like enhancement curves and for improving the performance of computer-aided detection systems.

Original languageEnglish (US)
Pages (from-to)1344-1354
Number of pages11
JournalAcademic Radiology
Volume13
Issue number11
DOIs
StatePublished - Nov 2006

Fingerprint

Breast
Magnetic Resonance Spectroscopy
Neoplasms
Pathology
ROC Curve
Breast Neoplasms
Biopsy

Keywords

  • blooming
  • Breast
  • CAD (or computer-aided-detection)
  • cancer
  • kinetics
  • morphology
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Morphologic Blooming in Breast MRI as a Characterization of Margin for Discriminating Benign from Malignant Lesions. / Penn, Alan; Thompson, Scott; Brem, Rachel; Lehman, Constance; Weatherall, Paul; Schnall, Mitchell; Newstead, Gillian; Conant, Emily; Ascher, Susan; Morris, Elizabeth; Pisano, Etta.

In: Academic Radiology, Vol. 13, No. 11, 11.2006, p. 1344-1354.

Research output: Contribution to journalArticle

Penn, A, Thompson, S, Brem, R, Lehman, C, Weatherall, P, Schnall, M, Newstead, G, Conant, E, Ascher, S, Morris, E & Pisano, E 2006, 'Morphologic Blooming in Breast MRI as a Characterization of Margin for Discriminating Benign from Malignant Lesions', Academic Radiology, vol. 13, no. 11, pp. 1344-1354. https://doi.org/10.1016/j.acra.2006.08.003
Penn, Alan ; Thompson, Scott ; Brem, Rachel ; Lehman, Constance ; Weatherall, Paul ; Schnall, Mitchell ; Newstead, Gillian ; Conant, Emily ; Ascher, Susan ; Morris, Elizabeth ; Pisano, Etta. / Morphologic Blooming in Breast MRI as a Characterization of Margin for Discriminating Benign from Malignant Lesions. In: Academic Radiology. 2006 ; Vol. 13, No. 11. pp. 1344-1354.
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abstract = "Rationale and Objectives: Develop a fully automated, objective method for evaluating morphology on breast magnetic resonance (MR) images and evaluate effectiveness of the new morphologic method for detecting breast cancers. Materials and Methods: We present a new automated method (morphologic blooming) for identifying and classifying breast lesions on MR that measures margin sharpness, a characteristic related to blooming, defined as rapid enhancement, with a border that is initially sharp but becomes unsharp after 7 minutes. Independent training sets (98 biopsy-proven lesions) and testing sets (179 breasts, 127 patients, acquired at five institutions) were used. Morphologic blooming was evaluated as a stand-alone feature and as an adjunct to kinetics using free-response receiver operating characteristic and sensitivity analysis. Dependence of false-positive (FP) rates on acquisition times and pathologies of contralateral breasts were evaluated. Results: Sensitivity of morphologic blooming was 80{\%} with 2.46 FP per noncancerous breast: FPs did not vary significantly by acquisition times. FPs varied significantly by pathologies of contralateral breasts (cancerous contralateral: 4.29 FP/breast; noncancerous contralateral: 0.48 FP/breast; P < .0001). Evaluation of 45 cancers showed suspicious morphologies on 10/15 (67{\%}) cancers with benign-like kinetics and suspicious kinetics on 5/10 (50{\%}) cancers with benign-like morphologies. Conclusion: We present a new, fully automated method of identifying and classifying margin sharpness of breast lesions on MR that can be used to direct radiologists' attention to lesions with suspicious morphologies. Morphologic blooming may have important utility for assisting radiologists in identifying cancers with benign-like kinetics and discriminating normal tissues that exhibit cancer-like enhancement curves and for improving the performance of computer-aided detection systems.",
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