Mother-to-child transmission of herpes simplex virus

Scott H. James, Jeanne S. Sheffield, David W. Kimberlin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Infections with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2), both alpha herpesviruses, are highly prevalent worldwide. Both HSV types commonly cause genital infection, which, when acquired or reactivated during pregnancy, carries with it the risk of transmission to the fetus or neonate. Women who acquire primary or first-episode genital herpes during pregnancy are at greater risk for transmitting the infection than are women with recurrent genital herpes. Because viral infection and reactivation are frequently asymptomatic, many affected women are unaware of their infection and risk of transmission to their infants. Neonatal HSV infection can have devastating long-term consequences, especially when the central nervous system (CNS) is involved. Treatment of affected neonates with intravenous acyclovir has improved outcomes but there is room for further improvement, especially in regard to CNS disease. Working with pregnant women to prevent mother-to-child transmission of HSV is an important component in reducing the overall disease burden of neonatal HSV infections.

Original languageEnglish (US)
Article numberpiu050
JournalJournal of the Pediatric Infectious Diseases Society
Volume3
Issue numberSUPPL1
DOIs
StatePublished - 2014

Fingerprint

Simplexvirus
Mothers
Herpes Genitalis
Infection
Infant, Newborn, Diseases
Newborn Infant
Pregnancy
Infectious Disease Transmission
Acyclovir
Herpesviridae
Central Nervous System Diseases
Human Herpesvirus 1
Virus Diseases
Pregnant Women
Fetus
Central Nervous System

Keywords

  • Herpes simplex virus type 1
  • Herpes simplex virus type 2
  • Perinatal transmission

ASJC Scopus subject areas

  • Infectious Diseases
  • Pediatrics, Perinatology, and Child Health

Cite this

Mother-to-child transmission of herpes simplex virus. / James, Scott H.; Sheffield, Jeanne S.; Kimberlin, David W.

In: Journal of the Pediatric Infectious Diseases Society, Vol. 3, No. SUPPL1, piu050, 2014.

Research output: Contribution to journalArticle

James, Scott H. ; Sheffield, Jeanne S. ; Kimberlin, David W. / Mother-to-child transmission of herpes simplex virus. In: Journal of the Pediatric Infectious Diseases Society. 2014 ; Vol. 3, No. SUPPL1.
@article{6e4b5a9b864a40fe88e91ac152933ede,
title = "Mother-to-child transmission of herpes simplex virus",
abstract = "Infections with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2), both alpha herpesviruses, are highly prevalent worldwide. Both HSV types commonly cause genital infection, which, when acquired or reactivated during pregnancy, carries with it the risk of transmission to the fetus or neonate. Women who acquire primary or first-episode genital herpes during pregnancy are at greater risk for transmitting the infection than are women with recurrent genital herpes. Because viral infection and reactivation are frequently asymptomatic, many affected women are unaware of their infection and risk of transmission to their infants. Neonatal HSV infection can have devastating long-term consequences, especially when the central nervous system (CNS) is involved. Treatment of affected neonates with intravenous acyclovir has improved outcomes but there is room for further improvement, especially in regard to CNS disease. Working with pregnant women to prevent mother-to-child transmission of HSV is an important component in reducing the overall disease burden of neonatal HSV infections.",
keywords = "Herpes simplex virus type 1, Herpes simplex virus type 2, Perinatal transmission",
author = "James, {Scott H.} and Sheffield, {Jeanne S.} and Kimberlin, {David W.}",
year = "2014",
doi = "10.1093/jpids/piu050",
language = "English (US)",
volume = "3",
journal = "Journal of the Pediatric Infectious Diseases Society",
issn = "2048-7207",
publisher = "Oxford University Press",
number = "SUPPL1",

}

TY - JOUR

T1 - Mother-to-child transmission of herpes simplex virus

AU - James, Scott H.

AU - Sheffield, Jeanne S.

AU - Kimberlin, David W.

PY - 2014

Y1 - 2014

N2 - Infections with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2), both alpha herpesviruses, are highly prevalent worldwide. Both HSV types commonly cause genital infection, which, when acquired or reactivated during pregnancy, carries with it the risk of transmission to the fetus or neonate. Women who acquire primary or first-episode genital herpes during pregnancy are at greater risk for transmitting the infection than are women with recurrent genital herpes. Because viral infection and reactivation are frequently asymptomatic, many affected women are unaware of their infection and risk of transmission to their infants. Neonatal HSV infection can have devastating long-term consequences, especially when the central nervous system (CNS) is involved. Treatment of affected neonates with intravenous acyclovir has improved outcomes but there is room for further improvement, especially in regard to CNS disease. Working with pregnant women to prevent mother-to-child transmission of HSV is an important component in reducing the overall disease burden of neonatal HSV infections.

AB - Infections with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2), both alpha herpesviruses, are highly prevalent worldwide. Both HSV types commonly cause genital infection, which, when acquired or reactivated during pregnancy, carries with it the risk of transmission to the fetus or neonate. Women who acquire primary or first-episode genital herpes during pregnancy are at greater risk for transmitting the infection than are women with recurrent genital herpes. Because viral infection and reactivation are frequently asymptomatic, many affected women are unaware of their infection and risk of transmission to their infants. Neonatal HSV infection can have devastating long-term consequences, especially when the central nervous system (CNS) is involved. Treatment of affected neonates with intravenous acyclovir has improved outcomes but there is room for further improvement, especially in regard to CNS disease. Working with pregnant women to prevent mother-to-child transmission of HSV is an important component in reducing the overall disease burden of neonatal HSV infections.

KW - Herpes simplex virus type 1

KW - Herpes simplex virus type 2

KW - Perinatal transmission

UR - http://www.scopus.com/inward/record.url?scp=84946749871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946749871&partnerID=8YFLogxK

U2 - 10.1093/jpids/piu050

DO - 10.1093/jpids/piu050

M3 - Article

VL - 3

JO - Journal of the Pediatric Infectious Diseases Society

JF - Journal of the Pediatric Infectious Diseases Society

SN - 2048-7207

IS - SUPPL1

M1 - piu050

ER -