Mouse models of alzheimer's disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transgenic mouse models have been created that mimic many of the neuropathologic and behavioral phenotypes of Alzheimer's disease (AD). Using mutations found in familial AD, the mouse models exhibit some of the cardinal features of the human disease. Wong et al. [1] and Higgins and Jacobsen [2] have written reviews of this topic. The current review extends a previous one [3] and will describe the similarities in the neuropathology of AD and the mouse models of the disease, specifically regarding neurodegeneration, and also describe treatments being developed using the mouse models.

Original languageEnglish (US)
Title of host publicationAbeta Peptide and Alzheimer's Disease: Celebrating a Century of Research
PublisherSpringer London
Pages259-273
Number of pages15
ISBN (Print)1852339616, 9781852339616
DOIs
StatePublished - 2007

Fingerprint

Alzheimer Disease
Transgenic Mice
Phenotype
Mutation
Neuropathology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

German, D. C. (2007). Mouse models of alzheimer's disease. In Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research (pp. 259-273). Springer London. https://doi.org/10.1007/978-1-84628-440-3_16

Mouse models of alzheimer's disease. / German, Dwight C.

Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. Springer London, 2007. p. 259-273.

Research output: Chapter in Book/Report/Conference proceedingChapter

German, DC 2007, Mouse models of alzheimer's disease. in Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. Springer London, pp. 259-273. https://doi.org/10.1007/978-1-84628-440-3_16
German DC. Mouse models of alzheimer's disease. In Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. Springer London. 2007. p. 259-273 https://doi.org/10.1007/978-1-84628-440-3_16
German, Dwight C. / Mouse models of alzheimer's disease. Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. Springer London, 2007. pp. 259-273
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