Transgenic mouse models have been created that mimic many of the neuropathologic and behavioral phenotypes of Alzheimer's disease (AD). Using mutations found in familial AD, the mouse models exhibit some of the cardinal features of the human disease. Wong et al.  and Higgins and Jacobsen  have written reviews of this topic. The current review extends a previous one  and will describe the similarities in the neuropathology of AD and the mouse models of the disease, specifically regarding neurodegeneration, and also describe treatments being developed using the mouse models.
|Original language||English (US)|
|Title of host publication||Abeta Peptide and Alzheimer's Disease|
|Subtitle of host publication||Celebrating a Century of Research|
|Number of pages||15|
|ISBN (Print)||1852339616, 9781852339616|
|State||Published - Dec 1 2007|
ASJC Scopus subject areas