Mouse tumor model for neurofibromatosis type 1

Kristine S. Vogel, Laura J. Klesse, Susana Velasco-Miguel, Kimberly Meyers, Elizabeth J. Rushing, Luis F. Parada

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by increased incidence of benign and malignant tumors of neural crest origin. Mutations that activate the protooncogene ras, such as loss of Nf1, cooperate with inactivating mutations at the p53 tumor suppressor gene during malignant transformation. One hundred percent of mice harboring null Nf1 and p53 alleles in cis synergize to develop soft tissue sarcomas between 3 and 7 months of age. These sarcomas exhibit loss of heterozygosity at both gene loci and express phenotypic traits characteristic of neural crest derivatives and human NF1 malignancies.

Original languageEnglish (US)
Pages (from-to)2176-2179
Number of pages4
JournalScience
Volume286
Issue number5447
DOIs
StatePublished - Dec 10 1999

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Neurofibromatosis 1
Sarcoma
Mutation
Neural Crest
Loss of Heterozygosity
Tumor Suppressor Genes
Neoplasms
Alleles
Incidence
Genes
Neural crest tumor

ASJC Scopus subject areas

  • General

Cite this

Vogel, K. S., Klesse, L. J., Velasco-Miguel, S., Meyers, K., Rushing, E. J., & Parada, L. F. (1999). Mouse tumor model for neurofibromatosis type 1. Science, 286(5447), 2176-2179. https://doi.org/10.1126/science.286.5447.2176

Mouse tumor model for neurofibromatosis type 1. / Vogel, Kristine S.; Klesse, Laura J.; Velasco-Miguel, Susana; Meyers, Kimberly; Rushing, Elizabeth J.; Parada, Luis F.

In: Science, Vol. 286, No. 5447, 10.12.1999, p. 2176-2179.

Research output: Contribution to journalArticle

Vogel, KS, Klesse, LJ, Velasco-Miguel, S, Meyers, K, Rushing, EJ & Parada, LF 1999, 'Mouse tumor model for neurofibromatosis type 1', Science, vol. 286, no. 5447, pp. 2176-2179. https://doi.org/10.1126/science.286.5447.2176
Vogel KS, Klesse LJ, Velasco-Miguel S, Meyers K, Rushing EJ, Parada LF. Mouse tumor model for neurofibromatosis type 1. Science. 1999 Dec 10;286(5447):2176-2179. https://doi.org/10.1126/science.286.5447.2176
Vogel, Kristine S. ; Klesse, Laura J. ; Velasco-Miguel, Susana ; Meyers, Kimberly ; Rushing, Elizabeth J. ; Parada, Luis F. / Mouse tumor model for neurofibromatosis type 1. In: Science. 1999 ; Vol. 286, No. 5447. pp. 2176-2179.
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