MR neurography of brachial plexus at 3.0 T with robust fat and blood suppression

Xinzeng Wang, Crystal Harrison, Yogesh K. Mariappan, Karthik Gopalakrishnan, Avneesh Chhabra, Robert E. Lenkinski, Ananth J. Madhuranthakam

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Purpose: To develop and evaluate magnetic resonance (MR) neurography of the brachial plexus with robust fat and blood suppression for increased conspicuity of nerves at 3.0 T in clinically feasible acquisition times. Materials and Methods: This prospective study was HIPAA compliant, with institutional review board approval and written informed consent. A low-refocusing-flip-angle three-dimensional (3D) turbo spin-echo (TSE) sequence was modified to acquire both in-phase and out-of-phase echoes, required for chemical shift (Dixon) reconstruction, in the same repetition by using partial echoes combined with modified homodyne reconstruction with phase preservation. This multiecho TSE modified Dixon (mDixon) sequence was optimized by using simulations and phantom studies and in three healthy volunteers. The sequence was tested in five healthy volunteers and was evaluated in 10 patients who had been referred for brachial plexopathy at 3.0 T. The images were evaluated against the current standard of care, images acquired with a 3D TSE short inversion time inversion recovery (STIR) sequence, qualitatively by using the Wilcoxon signed-rank test and quantitatively by using the Friedman two-way analysis of variance, with P <.05 considered to indicate a statistically significant difference. Results: Multiecho TSE-mDixon involving partial-echo and homodyne reconstruction with phase preservation achieved uniform fat suppression in half the imaging time compared with multiacquisition TSE-mDixon. Compared with 3D TSE STIR, fat suppression, venous suppression, and nerve visualization were significantly improved (P < .05), while arterial suppression was better but not significantly so (P = .06), with increased apparent signal-to-noise ratio in the dorsal nerve root ganglion and C6 nerve (P <.001) with the multiecho TSE-mDixon sequence. Conclusion: The multiecho 3D TSE-mDixon sequence provides robust fat and blood suppression, resulting in increased conspicuity of the nerves, in clinically feasible imaging times and can be used for MR neurography of the brachial plexus at 3.0 T.

Original languageEnglish (US)
Pages (from-to)538-546
Number of pages9
JournalRadiology
Volume283
Issue number2
DOIs
StatePublished - May 1 2017

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'MR neurography of brachial plexus at 3.0 T with robust fat and blood suppression'. Together they form a unique fingerprint.

  • Cite this