MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting

Luis M. De León-Rodríguez, Angelo Lubag, D. Gomika Udugamasooriya, Bettina Proneth, Rolf A. Brekken, Xiankai Sun, Thomas Kodadek, A. Dean Sherry

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r1 relaxivity of ∼48 mM-1 s-1 is shown to enhance MR images of tumors grown in mice in vivo.

Original languageEnglish (US)
Pages (from-to)12829-12831
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number37
DOIs
StatePublished - Sep 22 2010

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Peptoids
Vascular Endothelial Growth Factor Receptor-2
Polylysine
Dimers
Magnetic resonance imaging
Tumors
Molecular Weight
Molecular weight
Neoplasms
dendron
Intercellular Signaling Peptides and Proteins

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting. / De León-Rodríguez, Luis M.; Lubag, Angelo; Udugamasooriya, D. Gomika; Proneth, Bettina; Brekken, Rolf A.; Sun, Xiankai; Kodadek, Thomas; Dean Sherry, A.

In: Journal of the American Chemical Society, Vol. 132, No. 37, 22.09.2010, p. 12829-12831.

Research output: Contribution to journalArticle

De León-Rodríguez, Luis M. ; Lubag, Angelo ; Udugamasooriya, D. Gomika ; Proneth, Bettina ; Brekken, Rolf A. ; Sun, Xiankai ; Kodadek, Thomas ; Dean Sherry, A. / MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 37. pp. 12829-12831.
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