MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting

Luis M. De León-Rodríguez, Angelo Lubag, D. Gomika Udugamasooriya, Bettina Proneth, Rolf A. Brekken, Xiankai Sun, Thomas Kodadek, A. Dean Sherry

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r1 relaxivity of ∼48 mM-1 s-1 is shown to enhance MR images of tumors grown in mice in vivo.

Original languageEnglish (US)
Pages (from-to)12829-12831
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number37
DOIs
StatePublished - Sep 22 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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