MtDNA-encoded histocompatibility antigens

V. M. Dabhi, K. F. Lindahl

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Mitochondrially encoded H antigens are by-products of a system that has evolved in vertebrates to present peptides from intracellular pathogens on the cell surface for detection by CTLs, which can lyse the infected cell. CTL lines and clones with defined specificity against mitochondrial H antigens, which can be maintained in culture for long periods, offer a unique tool in mitochondrial genetics. Expression of polymorphic mitochondrial H antigens depends on both the presence and the activity of the corresponding mitochondrial genome, and CTLs can provide strong selection against cells displaying their cognate antigen.

Original languageEnglish (US)
Pages (from-to)466-485
Number of pages20
JournalMethods in Enzymology
Volume260
Issue numberC
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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