MtDNA-encoded histocompatibility antigens

V. M. Dabhi; K. F. Lindahl

doi:10.1016/0076-6879(95)60159-7

MtDNA-encoded histocompatibility antigens

V. M. Dabhi, K. F. Lindahl

Immunology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Mitochondrially encoded H antigens are by-products of a system that has evolved in vertebrates to present peptides from intracellular pathogens on the cell surface for detection by CTLs, which can lyse the infected cell. CTL lines and clones with defined specificity against mitochondrial H antigens, which can be maintained in culture for long periods, offer a unique tool in mitochondrial genetics. Expression of polymorphic mitochondrial H antigens depends on both the presence and the activity of the corresponding mitochondrial genome, and CTLs can provide strong selection against cells displaying their cognate antigen.

Original language	English (US)
Pages (from-to)	466-485
Number of pages	20
Journal	Methods in Enzymology
Volume	260
Issue number	C
DOIs	https://doi.org/10.1016/0076-6879(95)60159-7
State	Published - Jan 1 1995

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/0076-6879(95)60159-7

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AB - Mitochondrially encoded H antigens are by-products of a system that has evolved in vertebrates to present peptides from intracellular pathogens on the cell surface for detection by CTLs, which can lyse the infected cell. CTL lines and clones with defined specificity against mitochondrial H antigens, which can be maintained in culture for long periods, offer a unique tool in mitochondrial genetics. Expression of polymorphic mitochondrial H antigens depends on both the presence and the activity of the corresponding mitochondrial genome, and CTLs can provide strong selection against cells displaying their cognate antigen.

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MtDNA-encoded histocompatibility antigens

Abstract

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