mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Mauro Costa-Mattioli, Lisa M Monteggia

Research output: Contribution to journalReview article

164 Scopus citations

Abstract

The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.

Original languageEnglish (US)
Pages (from-to)1537-1543
Number of pages7
JournalNature neuroscience
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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