Multi-platform metabolomics and a genetic approach support the authentication of agarwood produced by Aquilaria crassna and Aquilaria malaccensis

Huy Truong Nguyen, Jung Eun Min, Nguyen Phuoc Long, Ma Chi Thanh, Thi Hong Van Le, Jeongmi Lee, Jeong Hill Park, Sung Won Kwon

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Agarwood, the resinous heartwood produced by some Aquilaria species such as Aquilaria crassna, Aquilaria malaccensis and Aquilaria sinensis, has been traditionally and widely used in medicine, incenses and especially perfumes. However, up to now, the authentication of agarwood has been largely based on morphological characteristics, a method which is prone to errors and lacks reproducibility. Hence, in this study, we applied metabolomics and a genetic approach to the authentication of two common agarwood chips, those produced by Aquilaria crassna and Aquilaria malaccensis. Primary metabolites, secondary metabolites and DNA markers of agarwood were authenticated by 1H NMR metabolomics, GC–MS metabolomics and DNA-based techniques, respectively. The results indicated that agarwood chips could be classified accurately by all the methods illustrated in this study. Additionally, the pros and cons of each method are also discussed. To the best of our knowledge, our research is the first study detailing all the differences in the primary and secondary metabolites, as well as the DNA markers between the agarwood produced by these two species.

Original languageEnglish (US)
Pages (from-to)136-144
Number of pages9
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume142
DOIs
StatePublished - Aug 5 2017

Keywords

  • H NMR metabolomics
  • Agarwood
  • Authentication
  • DNA markers
  • GC–MS metabolomics

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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