Abstract
We report the sequence of the cDNAs representing five independent splice forms of human placental RNase inhibitor (RI) mRNA. RI mRNAs differ principally in the 5′-untranslated region, which may include or lack a 68-nucleotide (nt) exon inserted at a splice site located only 20 nt upstream from the initiator AUG. At least three other exons may also abut the same splice site. This unusual and variable feature of the mRNA would suggest that secondary structure in the region of the start codon may differ among RI messages. A single copy of the RI gene exists in the human genome.
Original language | English (US) |
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Pages (from-to) | 525-531 |
Number of pages | 7 |
Journal | Gene |
Volume | 85 |
Issue number | 2 |
DOIs | |
State | Published - Dec 28 1989 |
Keywords
- RNase
- Recombinant DNA
- alterative splicing
- cDNA
- exon
- human RNase inhibitor
- start codon
ASJC Scopus subject areas
- Genetics