Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity

Baranda S. Hansen; Rehana Z. Hussain; Amy E. Lovett-Racke; James A. Thomas; Michael K. Racke

doi:10.1016/j.jneuroim.2005.11.006

Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity

Baranda S. Hansen, Rehana Z. Hussain, Amy E. Lovett-Racke, James A. Thomas, Michael K. Racke

Pediatrics

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66 Scopus citations

Abstract

Infections can trigger or exacerbate the course of Multiple Sclerosis, and both bacterial and viral agents have been implicated. These agents are recognized by host cells via pathogen-associated molecular patterns activating TLRs. We investigated the role that PAMPs play in the animal model Experimental Autoimmune Encephalomyelitis, and found various MyD88-dependent PAMPs can participate as the adjuvant to induce EAE. Studies with IRAK1-deficient mice suggest that signaling through TLRs is not required in the target organ to develop disease. This suggests that PAMPs play an important role in priming of autoreactive T cells in EAE and potentially MS.

Original language	English (US)
Pages (from-to)	94-103
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	172
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.11.006
State	Published - Mar 2006

Keywords

Autoimmune encephalomyelitis
Autoimmunity
Toll-like receptors

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2005.11.006

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title = "Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity",

abstract = "Infections can trigger or exacerbate the course of Multiple Sclerosis, and both bacterial and viral agents have been implicated. These agents are recognized by host cells via pathogen-associated molecular patterns activating TLRs. We investigated the role that PAMPs play in the animal model Experimental Autoimmune Encephalomyelitis, and found various MyD88-dependent PAMPs can participate as the adjuvant to induce EAE. Studies with IRAK1-deficient mice suggest that signaling through TLRs is not required in the target organ to develop disease. This suggests that PAMPs play an important role in priming of autoreactive T cells in EAE and potentially MS.",

keywords = "Autoimmune encephalomyelitis, Autoimmunity, Toll-like receptors",

author = "Hansen, {Baranda S.} and Hussain, {Rehana Z.} and Lovett-Racke, {Amy E.} and Thomas, {James A.} and Racke, {Michael K.}",

note = "Funding Information: This work was supported by grants from the NIH (NS 37513 and NS 44250) and NMSS (RG 3490-A-9) to MKR. AELR is a Harry Weaver Neuroscience Scholar of the National Multiple Sclerosis Society.",

year = "2006",

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AU - Hussain, Rehana Z.

AU - Lovett-Racke, Amy E.

AU - Thomas, James A.

AU - Racke, Michael K.

N1 - Funding Information: This work was supported by grants from the NIH (NS 37513 and NS 44250) and NMSS (RG 3490-A-9) to MKR. AELR is a Harry Weaver Neuroscience Scholar of the National Multiple Sclerosis Society.

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AB - Infections can trigger or exacerbate the course of Multiple Sclerosis, and both bacterial and viral agents have been implicated. These agents are recognized by host cells via pathogen-associated molecular patterns activating TLRs. We investigated the role that PAMPs play in the animal model Experimental Autoimmune Encephalomyelitis, and found various MyD88-dependent PAMPs can participate as the adjuvant to induce EAE. Studies with IRAK1-deficient mice suggest that signaling through TLRs is not required in the target organ to develop disease. This suggests that PAMPs play an important role in priming of autoreactive T cells in EAE and potentially MS.

KW - Autoimmune encephalomyelitis

KW - Autoimmunity

KW - Toll-like receptors

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Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity

Abstract

Keywords

ASJC Scopus subject areas

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