Mutations that impair androgen action

Jean D. Wilson, Jim Griffin III

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Development of the male phenotype during embryogenesis requires the action of androgenic hormone from the fetal testis. Mutations that cause resistance to androgen action impair normal male differentiation and result in a spectrum of developmental and functional disorders. Analysis of such mutations in humans and animals has provided insight into the normal pathway of androgen action and into sexual differentiation.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalTrends in Genetics
Volume1
Issue numberC
DOIs
StatePublished - 1985

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ASJC Scopus subject areas

  • Genetics

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