Myeloid diseases in the lung and pleura

Joseph D. Khoury, Weina Chen

Research output: Contribution to journalReview article

Abstract

Myeloid diseases detected as primary or secondary lesions in the lung and pleura are rare. Clinical presentations and radiographic results may vary significantly depending on the nature of the diseases. The most common diseases associated with lung and pleura involvement are myeloid sarcoma/acute myeloid leukemia (AML) and extramedullary hematopoiesis (EMH). AML typically represents localized involvement by systemic acute leukemia, while EMH is frequently secondary to underlying benign hematolymphoid disorders or myeloproliferative neoplasms. This review provides an overview of the pathogenesis, clinical presentations, radiologic/imaging studies, pathologic and genetic findings, and treatment/outcomes associated with myeloid diseases in the lung and pleura.

Original languageEnglish (US)
JournalSeminars in Diagnostic Pathology
DOIs
StateAccepted/In press - 2020

Keywords

  • Acute myeloid leukemia
  • Extramedullary hematopoiesis
  • Lung
  • Myeloid sarcoma
  • Myeloproliferative neoplasm
  • Pleura
  • Thalassemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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